1. GPCR/G Protein
  2. GnRH Receptor
  3. Luteinizing Hormone Releasing Hormone (LH-RH), salmon

Luteinizing Hormone Releasing Hormone (LH-RH), salmon  (Synonyms: Salmon GnRH; Salmon gonadotropin-releasing hormone; sGnRH)

目录号: HY-P0243 纯度: 99.69%
COA 产品使用指南 技术支持

Luteinizing Hormone Releasing Hormone (LH-RH), salmon (Salmon GnRH) 是在下丘脑中合成的垂体前体十肽,在控制生殖功能中起关键作用。

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Custom Peptide Synthesis

Luteinizing Hormone Releasing Hormone (LH-RH), salmon Chemical Structure

Luteinizing Hormone Releasing Hormone (LH-RH), salmon Chemical Structure

CAS No. : 86073-88-3

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     可免费申领三个不同产品的试用装。

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1 mg ¥880
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5 mg ¥1950
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10 mg ¥3500
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Luteinizing Hormone Releasing Hormone (LH-RH), salmon (Salmon GnRH) is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions.

体外研究
(In Vitro)

促黄体激素释放激素 (LHRH) 是控制生殖功能的关键激素。LHRH 通过激活 Gi-cAMP 细胞内信号通路作为抗有丝分裂因子。LHRH 可能作为黑色素瘤细胞增殖和转移行为的抑制因子[1]。下丘脑十肽促黄体激素释放激素 (LHRH) 通过刺激垂体促黄体激素 (LH) 和促卵泡激素 (FSH) 的释放,在控制生殖方面发挥核心作用,进而促进性腺功能并调节性类固醇分泌。LHRH 的作用是由高亲和力 G 蛋白偶联 LHRH 受体 (LHRH-R) 对垂体促性腺激素介导的。对 LHRH 的反应在不同条件下会有所不同,并且主要取决于给药方案和递送至促性腺激素细胞的剂量[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1212.31

Formula

C60H73N15O13

CAS 号
性状

固体

颜色

White to off-white

Sequence

{Glp}-His-Trp-Ser-Tyr-Gly-Trp-Leu-Pro-Gly-NH2

Sequence Shortening

{Glp}-HWSYGWLPG-NH2

中文名称

黄体激素释放激素 (LH-RH),蛙鱼

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
细胞实验: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Luteinizing Hormone Releasing Hormone (LH-RH), salmon 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Luteinizing Hormone Releasing Hormone (LH-RH), salmon
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