2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Mevalonic acid

Mevalonic acid (MVA) 是甲羟戊酸途径 (mevalonate pathway) 的前体物质，对细胞生长和增殖至关重要。Mevalonic acid 在体外能有效抑制 Simvastatin (HY-17502) 诱导的 C2C12 细胞活力下降，可用于肌病和心力衰竭的研究。

该游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式 Mevalonic acid lithium salt。

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Mevalonic acid Chemical Structure

Mevalonic acid Chemical Structure

CAS No. : 150-97-0

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Other Forms of Mevalonic acid:

Mevalonic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure[1][2].

体外研究
(In Vitro)

Mevalonic acid (80, 90, 100, 110 µM; 72 h) shows prevention of simvastatin-induced loss of viability of C2C12myotube cells in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mevalonic acid 相关抗体:

Cell Viability Assay[1]

Cell Line: C2C12 cells (simvastatin-induced)
Concentration: 80, 90, 100, 110 µM
Incubation Time: 72 h
Result: Showed no decline in cell viability.
Clinical Trial
分子量

148.16

Formula

C6H12O4
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (259 KB)

产品使用指南 (1538 KB)
参考文献

Mevalonic acid 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mevalonic acid150-97-0MVAEndogenous Metabolitemevalonate pathwaymyopathyheart failureC2C12Inhibitorinhibitorinhibit

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