2. Apoptosis
  3. RIP kinase
  4. Nec-4

Nec-4, 一个三环衍生物，是受体相互作用蛋白 1 (RIP1) 的一个有效抑制剂，其 IC50 值为 2.6 μM，Ki 值为 0.46 μM。

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Nec-4 Chemical Structure

Nec-4 Chemical Structure

CAS No. : 1041644-43-2

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Nec-4 相关抗体

Top Publications Citing Use of Products

查看 RIP kinase 亚型特异性产品:

查看所有亚型
RIPK1 RIPK2 RIPK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.

IC50 & Target

IC50: 2.6 μM (RIP1)[1].
体外研究
(In Vitro)

Nec-4 (compound 9) is a slightly better competitor than 7 with a lower Ki value that is similar to R-3. Nec-4 is again a slightly better competitor than Rac-3 with Ki and IC50 values comparable to 7 (Nec-4: IC50=2.6±0.1 μM, Ki=0.46±0.05 μM; 7: IC50=10.7±1.8 μM, Ki=4.5±0.9 μM). Overall, all three compounds cross-compete with each other but Nec-4 is able to more effectively displace both 20 and 26 in comparison to the parent compounds Rac-3 and 7, respectively. This suggests that Nec-4 binding likely significantly overlaps with both the Nec-1 and the Nec-3 binding sites.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nec-4 相关抗体:
分子量

305.73

Formula

C15H13ClFN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nec-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nec-41041644-43-2Nec4Nec 4RIP kinaseReceptor-interacting protein kinasesRIPKInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-18900
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