2. Immunology/Inflammation
  3. Interleukin Related
  4. Nosantine racemate

Nosantine racemate  (Synonyms: 诺次黄嘌呤外消旋体; NPT 15392 racemate)

目录号: HY-101687
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摩尔计算器

Nosantine racemate 是 Nosantine 的外消旋体。Nosantine是一种 IL-2 诱导剂或诱导 IL-2 的增强剂。

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Nosantine racemate Chemical Structure

Nosantine racemate Chemical Structure

CAS No. : 75166-67-5

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Nosantine racemate 相关抗体

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查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nosantine racemate is the racemate of Nosantine. Nosantine is an inducer of IL-2 or enhancer of IL-2 induction by phytohemagglutinin (PHA).

IC50 & Target

IL-2[1]
体外研究
(In Vitro)

The purine immunoenhancing drug Nosantine (NPT 15392) is evaluated as an inducer of IL-2 or enhancer of IL-2 induction by phytohemagglutinin (PHA). Nosantine is found to has significant enhancing activity on PHA induction of IL-2 by human lymphocytes over a wide range of concentrations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nosantine racemate 相关抗体:
体内研究
(In Vivo)

Multiple concomitant immune responses are assessed in individual rats following treatment with the immunoenhancing drugs, Isoprinosine (5 or 50 mg/kg), Nosantine (0.1 or 1.0 mg/kg) and Avridine (1 or 25 mg/kg), or the immunosuppressant, Cyclophosphamide (75 mg/kg). Rats treated with Nosantine (NPT 15392) have significantly enhanced DTH reactions at the 0.1 mg/kg dose. It can be concluded that NPT 15392 act as general immunostimulants in the rat, with avridine having the greatest effect under these experimental conditions[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

278.35

Formula

C14H22N4O2
CAS 号
中文名称

诺次黄嘌呤外消旋体
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[2]

Rats[2]
Animals in seven of the groups are also injected subcutaneously with various dosage regimens of the immunomodulating drugs, isoprinosine (ISO), Nosantine (NPT 15392), avridine (AVD) and cyclophosphamide (CY). Individual rats in each group receive drug treatments consisting of 5 or 50 mg/kg ISO, 0.1 or 1.0 mg/kg Nosantine, 1 or 25 mg/kg AVD, or 75 mg/kg CY. Injections of ISO, Nosantine and AVD are given at three separate time intervals in relation to injection with bovine serum albumin (BSA). Isoprinosine and Nosantine are given twice at the same time as each BSA injection and a third time 3 days before termination. All rats are sacrificed by asphyxiation with CO2 and assayed for immunocompetence 14 days after the initial BSA and KLH injections. Six separate immunoassays are performed to assess different immune responses in the same animal.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Nosantine racemate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nosantine75166-67-5NPT 15392诺次黄嘌呤外消旋体NPT15392NPT-15392Interleukin RelatedILInhibitorinhibitorinhibit

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