2. GPCR/G Protein
  3. Adenylate Cyclase
  4. Small Cardioactive Peptide B (SCPB)

Small Cardioactive Peptide B (SCPB) 

目录号: HY-P1495 纯度: 99.69%
COA 产品使用指南

摩尔计算器

Small Cardioactive Peptide B (SCPB) 是一种神经活性肽，刺激心脏和鳃组织的颗粒组分中的腺苷酸环化酶 (adenylate cyclase) 活性，EC50 分别为 0.1 和 1.0 μM。

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Custom Peptide Synthesis

Small Cardioactive Peptide B (SCPB) Chemical Structure

Small Cardioactive Peptide B (SCPB) Chemical Structure

CAS No. : 84746-43-0

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规格 价格 是否有货 数量
1 mg ￥700
In-stock
5 mg ￥1600
In-stock
10 mg ￥2300
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Small Cardioactive Peptide B (SCPB) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.

IC50 & Target

EC50: 0.1 μM (adenylate cyclase, in heart tissues), 1.0 μM (adenylate cyclase, in gill tissues)[1]
体外研究
(In Vitro)

Small cardioactive peptide B (SCPB) is a neurally active peptide endogenous to Aplysia. Small cardioactive peptide B (SCPB) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCPB) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCPB) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCPB) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCPB) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC50 values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCPB) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC50 value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCPB)is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCPB) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC50 of 0.1 and 1.0μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Small Cardioactive Peptide B (SCPB) 相关抗体:
分子量

1141.41

Formula

C52H80N14O11S2
CAS 号
性状

固体

颜色

White to off-white

Sequence

Met-Asn-Tyr-Leu-Ala-Phe-Pro-Arg-Met-NH2
Sequence Shortening

MNYLAFPRM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 50 mg/mL (43.81 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8761 mL 4.3805 mL 8.7611 mL
5 mM 0.1752 mL 0.8761 mL 1.7522 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Small Cardioactive Peptide B (SCPB) 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8761 mL 4.3805 mL 8.7611 mL 21.9027 mL
5 mM 0.1752 mL 0.8761 mL 1.7522 mL 4.3805 mL
10 mM 0.0876 mL 0.4381 mL 0.8761 mL 2.1903 mL
15 mM 0.0584 mL 0.2920 mL 0.5841 mL 1.4602 mL
20 mM 0.0438 mL 0.2190 mL 0.4381 mL 1.0951 mL
25 mM 0.0350 mL 0.1752 mL 0.3504 mL 0.8761 mL
30 mM 0.0292 mL 0.1460 mL 0.2920 mL 0.7301 mL
40 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5476 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Small Cardioactive Peptide B (SCPB)84746-43-0Adenylate CyclaseAdenylyl cyclaseInhibitorinhibitorinhibit

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目录号：
HY-P1495
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