2. Signaling Pathways
  3. Immunology/Inflammation
  4. Scavenger Receptor Class B type I (SR-BI）

Scavenger Receptor Class B type I (SR-BI） 

Scavenger receptor class B member 1; SRB1; CD36 and LIMPII analogous 1 (CLA-1); CD36 antigen-like 1

Scavenger receptor class B type I (SR-BI) is a physiologically relevant HDL receptor that mediates the selective uptake of HDL-derived cholesteryl esters (CEs) in vitro and in vivo. SR-BI is a member of the class B scavenger receptor family, which in mammals includes the cluster determinant 36 (CD36) family, lysosomal integral membrane protein II (LIMPII, a lysosomal protein), and SR-BII, an SR-BI isoform with an alternative C-terminal cytoplasmic tail. SR-BI is primarily located on the cell surface, where its expression is regulated by trophic hormones (adrenocorticotropic hormone [ACTH] or the gonadotropins luteinizing hormone [LH] or follicle-stimulating hormone [FSH]), as well as regulating steroid hormone production. SR-BI affects the function of multiple vascular cells associated with atherosclerosis. SR-BI is also involved in regulating platelet function and mediating platelet-HDL interactions[1].

Scavenger Receptor Class B type I (SR-BI） 相关产品 (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163541
    SMS121 Inhibitor 98.75%
    SMS121 是一种 CD36 抑制剂，KD 值约为 5 µM。SMS121 可减少急性髓系白血病细胞对脂质的摄取以及抑制细胞活力。SMS121 具有抗肿瘤的活性。
    SMS121
  • HY-119770
    HDL376 Inhibitor 98.62%
    HDL376 是一种清道夫受体 B 类 I 型 (SR-BI) 抑制剂。HDL376 直接抑制细胞和用纯化 SR-BI 重构的脂质体中 SR-BI 介导的脂质转运 (IC50 = 0.22 μM)。HDL376可用于动脉粥样硬化性冠状动脉疾病的研究。
    HDL376
  • HY-154857
    1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine Ligand
    1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine 是一种甘油磷酸胆碱，由磷酸甘油、胆碱和棕榈酸组成。它在体内的氧化应激位点积聚。而氧化磷脂 oxPC(CD36) 是 B 类清道夫受体 (CD36和SR-BI) 的有效配体，1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine 可能是 B 类清道夫受体的配体。氧化磷脂 (oxPLs) 在肿瘤凋亡中也起重要作用，可能在恶性胆管狭窄中升高。
    1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine
  • HY-P990352
    Anti-CD36 Antibody Inhibitor
    Anti-CD36 Antibody 是 CHO 表达的人源抗体，靶向 CD36。Anti-CD36 Antibody 带有 huIgG1 型重链和 huκ 型轻链，其预测的分子量 (MW) 为 150 kDa。Anti-CD36 Antibody 的同型对照可参考 Human IgG1 kappa, Isotype Control (HY-P99001)。
    Anti-CD36 Antibody
  • HY-168371
    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC
    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC (13-HODE-PC) 是一种氧化磷脂，在 sn-1 和 sn-2 位分别含有 Palmitic acid (HY-N0830) 和 13(S)-HODE (HY-113884B)。1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC 能够竞争 125I-NO2-LDL（5 g/ml）与 CD36 转染的 293 细胞的结合，其 IC50 为大于 200 μM。
    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC
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