2. NF-κB MAPK/ERK Pathway Autophagy Metabolic Enzyme/Protease
  3. NF-κB JNK Autophagy Endogenous Metabolite
  4. Tomatidine hydrochloride

Tomatidine hydrochloride  (Synonyms: 盐酸番茄碱)

目录号: HY-N2149A 纯度: 99.58%
COA 产品使用指南

摩尔计算器

Tomatidine hydrochloride 通过阻断 NF-κB 和 JNK 信号发挥抗炎作用。Tomatidine hydrochloride 激活哺乳动物细胞或秀丽隐杆线虫中的自噬 (autophagy)。

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Tomatidine hydrochloride Chemical Structure

Tomatidine hydrochloride Chemical Structure

CAS No. : 6192-62-7

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规格 价格 是否有货 数量
5 mg ￥500
In-stock
10 mg ￥700
In-stock
25 mg ￥1400
In-stock
50 mg ￥2200
In-stock
100 mg ￥3500
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Tomatidine hydrochloride:

Tomatidine hydrochloride 相关抗体

Top Publications Citing Use of Products

    Tomatidine hydrochloride purchased from MCE. Usage Cited in: FASEB J. 2019 Feb;33(2):2574-2586.  [Abstract]

    Tomatidine attenuates osteoclastogenesis by inhibiting the MAPK, NF-kB, and PI3K/Akt signaling pathways in vitro.

    查看 NF-κB 亚型特异性产品:

    查看所有亚型
    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    查看 JNK 亚型特异性产品:

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    JNK1 JNK2 JNK3 JNK

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling[1]. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans[2].

    IC50 & Target[1]

    p65

     

    JNK

     

    体外研究
    (In Vitro)

    Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Tomatidine hydrochloride 相关抗体:
    分子量

    452.11

    Formula

    C27H46ClNO2
    CAS 号
    性状

    固体

    颜色

    White to yellow

    中文名称

    盐酸番茄碱
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性数据
    细胞实验： 

    Methanol 中的溶解度 : 12.5 mg/mL (27.65 mM; 超声助溶)

    Ethanol 中的溶解度 : 3.45 mg/mL (7.63 mM; 超声助溶)

    DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

    H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.2119 mL 11.0593 mL 22.1185 mL
    5 mM 0.4424 mL 2.2119 mL 4.4237 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.58%

    COA (290 KB) HNMR (287 KB) RP-HPLC (212 KB) MS (80 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [1]

    RAW 264.7 cells, derived from murine macrophages, are cultured in DMEM supplemented with 10% endotoxin-free, heat-inactivated fetal calf serum, Penicillin (100 units/mL), and Streptomycin (100 μg/mL) in a 5% CO2 atmosphere at 37 °C in a humidified incubator. For all assay, cell is plated at 2×105 cells/cm2 in culture dishes or plates. Treatment with vehicle (0.1% DMSO or 0.1% ethanol), test compounds and/or LPS is carried out under serum-free conditions[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Tomatidine hydrochloride 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    Ethanol / Methanol 1 mM 2.2119 mL 11.0593 mL 22.1185 mL 55.2963 mL
    5 mM 0.4424 mL 2.2119 mL 4.4237 mL 11.0593 mL
    Methanol 10 mM 0.2212 mL 1.1059 mL 2.2119 mL 5.5296 mL
    15 mM 0.1475 mL 0.7373 mL 1.4746 mL 3.6864 mL
    20 mM 0.1106 mL 0.5530 mL 1.1059 mL 2.7648 mL
    25 mM 0.0885 mL 0.4424 mL 0.8847 mL 2.2119 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tomatidine6192-62-7盐酸番茄碱NF-κBJNKAutophagyEndogenous MetaboliteNuclear factor-κBNuclear factor-kappaBc-Jun N-terminal kinaseanti-inflammatorychemopreventionLPS-stimulatedmousemacrophagesphosphorylationInhibitorinhibitorinhibit

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    目录号：
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