2. Metabolic Enzyme/Protease Apoptosis
  3. Dipeptidyl Peptidase Ferroptosis Apoptosis
  4. Vildagliptin dihydrate

Vildagliptin dihydrate  (Synonyms: 维格列汀二水合物; LAF237 dihydrate; NVP-LAF 237 dihydrate)

目录号: HY-14291A
产品使用指南

摩尔计算器

Vildagliptin dihydrate (LAF237 dihydrate) 是一种有效且稳定的选择性二肽基肽酶IV (DPP-IV) 抑制剂，在人 Caco-2 细胞中抑制 DPP-IV 的 IC50 为 3.5 nM。Vildagliptin dihydrate 具有出色的口服生物利用度和有效的降血糖活性。

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Vildagliptin dihydrate Chemical Structure

Vildagliptin dihydrate Chemical Structure

CAS No. : 2133364-01-7

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Vildagliptin dihydrate 的其他形式现货产品:

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Vildagliptin dihydrate 相关抗体

Top Publications Citing Use of Products

    Vildagliptin dihydrate purchased from MCE. Usage Cited in: Int J Mol Sci. 2022, 23(22), 14101

    qPCR Assay. Vildagliptin (5 µM; 0, 6, 12, 24, 48, 72 h) stimulates the expression of IL-6 in HaCaT cells.

    Vildagliptin dihydrate purchased from MCE. Usage Cited in: Cancer Lett. 2018 Apr 28;420:26-37.  [Abstract]

    Representative images showing visible metastatic nodules in the lungs of mice treated with Vildagliptin and fed an high-fat diet (HFD).

    查看 Dipeptidyl Peptidase 亚型特异性产品:

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    DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity[1].

    IC50 & Target

    IC50: 3.5 nM (DPP-IV, in human Caco-2 cells)[1]
    体外研究
    (In Vitro)

    Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Vildagliptin dihydrate 相关抗体:
    体内研究
    (In Vivo)

    Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice[2].
    Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male db/db mice (BKS) and wildtype mice[2]
    Dosage: 35 mg/kg
    Administration: Oral gavage; once daily; for 6 weeks
    Result: Increased plasma active GLP-1 levels (22.63±1.19 vs. 11.69±0.44).
    Animal Model: Obese male Zucker rats[1]
    Dosage: 10 µmol/kg (Pharmacokinetic Analysis)
    Administration: Orally
    Result: Significantly decreased glucose excursions and stimulate insulin secretion.
    Clinical Trial
    分子量

    339.43

    Formula

    C17H29N3O4
    CAS 号
    中文名称

    维达列汀二水合物；维格列汀二水合物
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Vildagliptin dihydrate 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Vildagliptin dihydrate2133364-01-7LAF237 dihydrateNVP-LAF 237 dihydrate维达列汀二水合物维格列汀二水合物Dipeptidyl PeptidaseFerroptosisApoptosisDPPdipeptidylpeptidaseDPP-IVCaco-2cellsantihyperglycemicInhibitorinhibitorinhibit

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