2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase
  4. Aβ42-IN-1 free base

Aβ42-IN-1 free base 是一种具有口服活性的，高暴露的 γ- 分泌酶 (γ-secretase) 调节剂。Aβ42-IN-1 free base 可显著降低小鼠脑 Aβ42 水平，IC50 值为 0.091 μM。Aβ42-IN-1 free base 可用于阿尔茨海默病的研究。

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Aβ42-IN-1 free base Chemical Structure

Aβ42-IN-1 free base Chemical Structure

CAS No. : 2434633-17-5

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Other Forms of Aβ42-IN-1 free base:

Aβ42-IN-1 free base 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease[1].

体内研究
(In Vivo)

Aβ42-IN-1 free base treatment shows that the CLint value is 84.7 µL/min/mg protein[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nonfasted 8-week-old male ddY mice[1]
Dosage: 30 mg/kg
Administration: p.o. (Pharmacokinetic Analysis)
Result: The CLint is 84.7 µL/min/mg protein.
分子量

462.54

Formula

C29H26N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aβ42-IN-1 free base 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ42-IN-12434633-17-5γ-secretaseGamma secretaseoralAβ42Alzheimer’sdiseasehighbrainexposureInhibitorinhibitorinhibit

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