2. Metabolic Enzyme/Protease Neuronal Signaling
  3. Adenosine Kinase
  4. A-286501

A-286501 是具有口服活性和强效的环状核苷酸腺苷激酶 (adenosine kinase) 抑制剂，其 IC50 值为 0.47 nM，表现出镇痛和消炎效果。A-286501 能减少小动物模型中的急性 (热)、炎性 (福尔马林和卡拉胶) 和神经性 (L5/L6神经结扎和链脲佐菌素诱导的糖尿病) 疼痛的痛觉反应。A-286501 还降低了 Carrageenan (HY-125474) 诱导受伤足部的水肿和髓过氧化物酶活性。A-286501 有望用于镇痛和抗炎剂的研究。

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A-286501 Chemical Structure

A-286501 Chemical Structure

CAS No. : 483341-15-7

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A-286501 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

A-286501 is an orally active and potent carbocyclic nucleoside adenosine kinase inhibitor with an IC50 value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents[1].

分子量

328.17

Formula

C11H14BrN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

A-286501 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-286501483341-15-7A286501A 286501Adenosine KinaseADKorally activeadenosine kinaseanalgesicanti-inflammatorynociceptionpaw edemamyeloperoxidaseInhibitorinhibitorinhibit

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产品名称：
A-286501
目录号：
HY-116005
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