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  4. A 9387

A9387是一种Tn3编码的解决酶蛋白，它促进两个直接重复的重组位点之间的特定位点重组反应。已经分离出几种抑制这种事件的抑制剂。在这项研究中，四种抑制剂在重组反应的不同步骤上进行了测试。两种抑制剂，A9387和A1062，抑制了解决酶与res位点的结合。此外，DNase I足迹实验表明，在某些浓度的A9387和A1062下，解决酶更偏好与含有重组交叉点的res位点I结合。另外两种抑制剂A20812和A21960不影响解决酶与DNA的结合和弯曲，但抑制了解决酶与两个直接重复的res位点之间的同步形成。

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A 9387 Chemical Structure

A 9387 Chemical Structure

CAS No. : 3161-15-7

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A 9387 相关抗体

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  • 生物活性

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生物活性

A9387 is a Tn3-encoded resolvase protein that promotes site-specific recombination reactions between two directly repeated recombination sites. Several inhibitors have been isolated that inhibit this event. In this study, four inhibitors were tested at different steps of the recombination reaction. Two inhibitors, A9387 and A1062, inhibited the binding of resolvase to the res site. In addition, DNase I footprinting experiments showed that at certain concentrations of A9387 and A1062, resolvase preferred to bind to res site I containing the recombination junction. Two other inhibitors, A20812 and A21960, did not affect the binding and bending of resolvase to DNA but inhibited the formation of a synteny between resolvase and two directly repeated res sites.

分子量

444.95

Formula

C12H6Br2Cl2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

A 9387 相关分类

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Keywords:

A 93873161-15-7GalosfenA9387A-9387OthersInhibitorinhibitorinhibit

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