2. Membrane Transporter/Ion Channel
  3. BCRP
  4. ABCG2-IN-3

ABCG2-IN-3 (Compound 52) 是乳腺癌耐药蛋白 (ABCG2) 的选择性抑制剂，IC50 为 0.238 µM 。ABCG2-IN-3 克服 ABCG2 介导的对 SN-38 的抗性并抑制 ATPase 活性。

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ABCG2-IN-3 Chemical Structure

ABCG2-IN-3 Chemical Structure

CAS No. : 1942919-63-2

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ABCG2-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ABCG2-IN-3 (Compound 52) is a selective inhibitor for breast cancer resistance protein (ABCG2), with an IC50 of 0.238 µM. ABCG2-IN-3 reverses the ABCG2-mediated resistance toward SN-38 and inhibit the ATPase activity[1].

体外研究
(In Vitro)

ABCG2-IN-3 对细胞 MDCK II BCRP 和 MDCK 野生型具有细胞毒性，CI50s 分别为 5.82 和 6.55 μM[1]。
ABCG2-IN-3 抑制 ATPase，IC50 为 0.038 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ABCG2-IN-3 相关抗体:
分子量

451.34

Formula

C25H20Cl2N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ABCG2-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABCG2-IN-31942919-63-2BCRPBreast cancer resistance proteinABCG2MDCKMDCK II BCRPMDRInhibitorinhibitorinhibit

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