Ac-RYYRWK-NH2 TFA 

Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [³H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a K_d of 0.071 nM, but has no affinity for μ-, κ- or δ-opioid receptors^[1].

[3H]ac-RYYRWK-NH2 binding to rat cortical membranes revealed a single high affinity site for [3H]ac-RYYRWK-NH2 (K_d=0.071 nM)^[1].
Naloxone benzoylhydrazone displaced [3H]acRYYRWK-NH2 binding to rat cortical membranes (K_i=104 nM) and human ORL1 (K_i=136 nM) as well as [125I]Tyr14-NC-OH to ORL1 (K_i=37 nM) has no affinity for μ-, κ- or δ-opioid receptors^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1126.19

C₅₁H₇₀F₃N₁₅O₁₁

408305-09-9

Ac-RYYRWK-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. C T Dooley, et al. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.  [Content Brief]

  [2]. M Ho, et al, Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle. Br J Pharmacol. 2000 Sep;131(2):349-55.  [Content Brief]