2. Inhibitory Antibodies
  3. Adecatumumab

Adecatumumab  (Synonyms: 阿德木单抗; MT 201; Anti-Human EPCAM Recombinant Antibody)

目录号: HY-P99278 纯度: 99.54%
COA

摩尔计算器

Adecatumumab (Anti-Human EPCAM Recombinant Antibody; MT201) 是 IgG1 同型的全人单克隆抗体，靶向人 EpCAM。Adecatumumab 在几乎所有腺癌中都有表达，其活性与 K-Ras 状态无关。

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CAS No. : 503605-66-1

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Adecatumumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Adecatumumab (Anti-Human EPCAM Recombinant Antibody; MT201) is a full human monoclonal antibody of the IgG1 isotype, targeting human EpCAM. Adecatumumab is expressed in almost all adenocarcinomas, and its activity is not dependent of K-Ras status[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
IC50 & Target

Human EPCAM[1]
体外研究
(In Vitro)

Adecatumumab (4 μM; 18 h) shows diverse kinetic binding activities among human Adecatumumab and murine Adecatumumab in B16/EpCAM 3E3 cells[2].
Adecatumumab (0.1 ng/mL-0.1 mg/mL; 4 h) shows a dose-dependent Antibodies depend on cell-mediated cytotoxicity (ADCC) activity in natural killing (NK) cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Adecatumumab 相关抗体:
体内研究
(In Vivo)

Adecatumumab (300 μg/mouse; i.v. bolus injection; 3 times per week) inhibits tumor growth in B16/EpCAM xenograft tumor model in mice, both of human adecatumumab and mu-adecatumumab[2].
Both human adecatumumab and mu-adecatumumab (300 μg/mouse; i.v. bolus injection; single dose) exhibit a bi-exponential curve progression of serum concentration with an early distribution phase between 0 and 10 h and a terminal elimination phase[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female immunocompetent C57BL/6 mice (6-10 weeks old) with B16/EpCAM (i.v.)[2]
Dosage: 250 μg/mouse and 600 μg/mouse for human Adecatumumab; 125 μg/mouse and 300 μg/mouse for murine Adecatumumab
Administration: 250 μg/mouse and 600 μg/mouse for human Adecatumumab; 125 μg/mouse and 300 μg/mouse for murine Adecatumumab
Result: Both of them exhibited anti-tumor activity against B16/EpCAM cells in mice.
Although human adecatumumab inhibited the size of tumor colonies mice, the number of colonies was only slightly reduced after treatment without significant difference.
In contrast, mu-adecatumumab induced a highly significant reduction in the number of lung tumor colonies by >85%, and the few remaining tumor colonies were of very small size.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

阿德木单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料

纯度: 99.54%

COA (173 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Adecatumumab 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adecatumumab503605-66-1MT 201 Anti-Human EPCAM Recombinant Antibody阿德木单抗MT201MT-201Othersadenocarcinomasfull human monoclonal antibodyK-RasInhibitorinhibitorinhibit

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