2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Autophagy Apoptosis PI3K/Akt/mTOR MAPK/ERK Pathway
  3. EGFR Autophagy Apoptosis c-Met/HGFR Akt p38 MAPK
  4. Afatinib (dimaleate) (Standard)

Afatinib (dimaleate) (Standard)  (Synonyms: 双马来酸盐阿法替尼 (Standard))

目录号: HY-10261AR 纯度: ≥98%
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Afatinib (dimaleate) (Standard)是 Afatinib (dimaleate) 的分析标准品。本产品用于研究及分析应用。Afatinib (BIBW 2992) dimaleate 是一种口服有效且不可逆的 ErbB 家族 (EGFR 和 HER2) 双特异性抑制剂，对 EGFRwt, EGFRL858R, EGFRL858R/T790M 和 HER2 的 IC

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Afatinib (dimaleate) (Standard) Chemical Structure

Afatinib (dimaleate) (Standard) Chemical Structure

CAS No. : 850140-73-7

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生物活性

Afatinib (dimaleate) (Standard) is the analytical standard of Afatinib (dimaleate). This product is intended for research and analytical applications. Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.

分子量

718.08

Formula

C32H33ClFN5O11
CAS 号
中文名称

阿法替尼双马来酸酯 (Standard)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Afatinib (dimaleate) (Standard) 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Afatinib (dimaleate) (Standard)850140-73-7阿法替尼双马来酸酯 (Standard)EGFRAutophagyApoptosisc-Met/HGFRAktp38 MAPKEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BNSCLCH1666H3255NCI-H1975NIH-3T3 cellsA431ESCCHER2AKTHKESC-1HKESC-2SLMT-1EC-1anticancerorally activelung cancerInhibitorinhibitorinhibit

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