2. Apoptosis
  3. Apoptosis
  4. AG6033

AG6033是一种潜在的新型CRBN调节剂。AG6033通过调控CRBN与多种抗肿瘤靶蛋白的相互作用抑制多种肿瘤细胞。AG6033可引起GSPT1和IKZF1的降解，且AG6033诱导CRBN依赖的细胞毒性作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

AG6033 Chemical Structure

AG6033 Chemical Structure

CAS No. : 329706-62-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

AG6033 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect[1].

IC50 & Target

CRBN

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.853 μM
Compound: AG6033
Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTS assay
Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTS assay
[PMID: 35413617]
体外研究
(In Vitro)

AG6033 (0.064-40 μM, 4 h) has potent inhibition ability against A549[1].
AG6033 (1-10 μM, 24 h) significantly promotes apoptosis of A549 cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AG6033 相关抗体:

Cell Proliferation Assay

Cell Line: A549 cells[1]
Concentration: 0.064 μM, 0.32 μM, 1.6 μM, 8 μM, and 40 μM
Incubation Time: 4 h
Result: Exhibited potent inhibitory ability against A549, with an IC50 of 0.853 μM.

Apoptosis Analysis

Cell Line: A549 cells[1]
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 24 h
Result: Significantly promoted apoptosis of A549 cells in a dose-dependent manner, and the proportion of late apoptotic cells were 5.39%, 22.0%, and 29.1%, respectively.
分子量

517.53

Formula

C30H23N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AG6033 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AG6033329706-62-9AG 6033AG-6033ApoptosisMultiple myelomaA549 cellsAntitumorApoptosis assayWestern blot analysisMolecular dockingInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
AG6033
目录号：
HY-143435
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z