2. Others Metabolic Enzyme/Protease
  3. Fluorescent Dye MMP
  4. Ageladine A dihydrochloride

Ageladine A dihydrochloride 是可以从海洋海绵 Agelas nakamurai 中分离得到的基质金属蛋白酶 (MMP) 抑制剂，具有抗血管生成作用。Ageladine A dihydrochloride 不仅能抑制 MMP-2，还能抑制MMP-1、MMP-8、MMP-9、MMP-12 和 MMP-13，其 IC50 值分别为 4.65 μM、2.79 μM、907．12 nM、1.83 μM、767.57 nM、1.09 μM。Ageladine A dihydrochloride 是一种 pH 敏感的膜通透性染料，在紫外线激发下，会在蓝绿色范围内发出荧光，最大吸收峰为 370 nm。此外，Ageladine A dihydrochloride 可作为可靠稳定的荧光 pH 传感器，可用于检测细胞内 pH 值的变化。

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Ageladine A dihydrochloride Chemical Structure

Ageladine A dihydrochloride Chemical Structure

CAS No. : 2757574-06-2

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Ageladine A dihydrochloride 相关抗体

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ageladine A dihydrochloride is an inhibitor of matrix metalloproteinase (MMP) isolated from the marine sponge Agelas nakamurai, possessing anti-angiogenic activity. Ageladine A dihydrochloride not only inhibits MMP-2 but also MMP-1, MMP-8, MMP-9, MMP-12, and MMP-13, with IC50 values of 4.65 μM, 2.79 μM, 907.12 nM, 1.83 μM, 767.57 nM, and 1.09 μM, respectively. Additionally, Ageladine A dihydrochloride is a pH-sensitive membrane-permeable dye that emits fluorescence in the blue-green range upon UV excitation, featuring a maximum absorption peak at 370 nm. Furthermore, Ageladine A dihydrochloride serves as a reliable and stable fluorescent pH sensor for detecting changes in intracellular pH values[1][2].

IC50 & Target[1]

MMP-1

2.79 μM (IC50)

MMP-2

4.65 μM (IC50)

MMP-8

907.12 nM (IC50)

MMP-9

1.83 μM (IC50)

MMP-12

767.57 nM (IC50)

MMP13

1.09 μM (IC50)

分子量

429.93

Formula

C10H9Br2Cl2N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ageladine A dihydrochloride 相关分类

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Keywords:

Ageladine A2757574-06-2Fluorescent DyeMMPMatrix metalloproteinasesSecondary metaboliteMarine spongepH sensorTransparent animalImagingAgelasAnti-angiogenesisInhibitorinhibitorinhibit

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