Ailanthoidol 

Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion^[1][2].

Ailanthoidol (20 μM; 24-72 hours) showed no cytotoxicity toward RAW264.7 macrophages^[1].
Ailanthoidol (1.25-20 μM; 24 hours) suppresses the generation of nitric oxide (NO) and prostaglandin E2 , aswell as theexpression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) in RAW264.7 cells^[1].
Ailanthoidol (1.25-20 μM; 24 hours) inhibits the production of inflammatory cytokines induced by LPS in RAW264.7 cells, including interleukin (IL)-1b and IL-6^[1].
Ailanthoidol suppresses NF-kB activation by blocking Ik-Ba degradation^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ailanthoidol (0.1-10 mg/kg; i.g.; 24 hours and 1 hours before LPS was injected, for 5 days) protects BALB/c mice from LPS (25mg/kg)-induced endotoxin shock, possibly through inhibition of the production of inflammatory cytokines and NO^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

326.34

C₁₉H₁₈O₅

156398-61-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jin-Kyung Kim, et al. Ailanthoidol suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice. J Cell Biochem. 2011 Dec;112(12):3816-23.  [Content Brief]

  [2]. Yean-Jang Lee, et al. Inhibitory effect of ailanthoidol on 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin. Oncol Rep. 2006 Oct;16(4):921-7.  [Content Brief]