ALK-IN-21 

ALK-IN-21 (Compound B10), a potent ALK inhibitor for ALKG1202R mutation, exhibits remarkable enzymatic inhibitory potency with IC₅₀ values of 4.59 nM, 2.07 nM and 5.95 nM toward ALK^WT, ALK^L1196M and ALK^G1202R, respectively. ALK-IN-21 efficiently inhibits the proliferation of ALK-positive Karpas299 and H2228 cells both with IC₅₀ values of 0.07 μM. ALK-IN-21 can be used for the research of anaplastic large cell lymphoma^[1].

IC₅₀: 2.07 nM (ALK^{L1196M), 4.59 nM (ALKWT), 5.95 nM (ALKG1202R)[1]}

ALK-IN-21 (Compound B10) inhibits the proliferation of Karpas299, H2228 and HCT116 cells with IC₅₀ values of 0.07, 0.07 and 5.53 μM, respectively^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

809.48

C₃₅H₄₅ClN₆O₆S₄

2901889-01-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xinyue Wang, et al. Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel ALK inhibitors. Bioorg Med Chem. 2022 Jul 15;66:116794.  [Content Brief]