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AM-1488 是一种有效的、具有口服活性的甘氨酸受体 (GlyR) 增效剂 (hGlyRα3 EC50=0.45 μM)。

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AM-1488 Chemical Structure

AM-1488 Chemical Structure

CAS No. : 2079895-60-4

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AM-1488 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC50=0.45 μM)[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T EC50
0.45 μM
Compound: 20-AM-1488
Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as potentiation of glycine-induced increase in chloride ion flux after 4 mins by membrane potential blue dye based FLIPR assay
Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as potentiation of glycine-induced increase in chloride ion flux after 4 mins by membrane potential blue dye based FLIPR assay
[PMID: 28001399]
体外研究
(In Vitro)

AM-1488 also potentiates native GlyRs in mouse spinal-cord neurons, which express mostly GlyRα1(β) and GlyRα3(β)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AM-1488 相关抗体:

Cell Viability Assay[1]

Cell Line: Mouse spinal-cord neuron
Concentration: 0.5 μM
Incubation Time: 10 min
Result: Increased the peak current evoked by a puff of 20 µM glycine in five out of five cells, from an average of 50.8 pA to an average of 222.2 pA.
体内研究
(In Vivo)

AM-1488 (oral gavage; 20 mg/kg; once) treatment significantly reverse mechanical allodynia induced by nerve injury in a mouse model of neuropathic pain, without being confounded by sedation or motor side effects[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse model of spared nerve injury (SNI)[1]
Dosage: 20 mg/kg
Administration: Oral gavage; 20 mg/kg; once
Result: Produced a significant 94% reversal of tactile allodynia, and the unbound brain concentration was 2.8- and 1.6-fold higher than the mouse GlyRα1 and GlyRα3 EC50 values, respectively.
Animal Model: Naive mice[1]
Dosage: 20 mg/kg
Administration: Oral gavage; 20 mg/kg; once
Result: Showed not significantly different from mice treated with vehicle.
分子量

383.42

Formula

C19H17N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AM-1488 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM-14882079895-60-4AM1488AM 1488Othersoral activityglycine receptormouse spinal-cord neuronInhibitorinhibitorinhibit

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产品名称：
AM-1488
目录号：
HY-147367
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