2. Cell Cycle/DNA Damage Apoptosis
  3. Eukaryotic Initiation Factor (eIF) Apoptosis
  4. AMC-01

AMC-01 是一种有效的化学探针，可以调节 eIF2-α 活性。AMC-01 通过诱导蛋白激酶 RNA 激活 (PKR) 激酶和核因子 κ b (NF-κB)。AMC-01 可抑制细胞凋亡 (apoptosis)。

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AMC-01 Chemical Structure

AMC-01 Chemical Structure

CAS No. : 1047978-71-1

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规格 价格 是否有货 数量
1 mg ￥4450
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AMC-01 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMC-01 is a potent chemical probe that regulates eIF2-α activity. AMC-01 induces protein kinase RNA activation (PKR) kinase and nuclear factor κb (NF-κB). AMC-01 inhibits apoptosis[1].

体外研究
(In Vitro)

AMC-01 (25 μM, 2 h) 对 Thapsigargin (HY-13433) 诱导的大鼠神经祖细胞 CSM14.1 凋亡具有抑制作用[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AMC-01 相关抗体:

Western Blot Analysis[1]

Cell Line: CSM 14.1
Concentration: 25 μM
Incubation Time: 2 h
Result: Increased phosphorylation of eIF2-α , p38 MAPK and NF-κB p65.
分子量

555.42

Formula

C27H27BrN2O6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

AMC-01 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMC-011047978-71-1AMC01AMC 01Eukaryotic Initiation Factor (eIF)ApoptosiseIF2-αCSM 14.1NF-κBMolecular probeInhibitorinhibitorinhibit

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目录号：
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