2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Ametantrone

Ametantrone  (Synonyms: NSC 196473; NSC 290813)

目录号: HY-13550
产品使用指南

摩尔计算器

Ametantrone (NSC 196473) 是一种插入 DNA 并诱导拓扑异构酶 II (TOP2) 介导的 DNA 断裂的抗肿瘤剂。

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Ametantrone Chemical Structure

Ametantrone Chemical Structure

CAS No. : 64862-96-0

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Customer Review

Ametantrone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa EC50
0.17 μg/mL
Compound: 2
Effective concentration required to inhibit by 50% the growth of HeLa S3 cells
Effective concentration required to inhibit by 50% the growth of HeLa S3 cells
[PMID: 3172129]
HeLa IC50
0.9 μM
Compound: Ametantrone
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 28342691]
HeLa IC50
0.9 μM
Compound: Ametantrone
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 27521587]
HeLa ED50
3.1 mM
Compound: AM
Effective concentration against cell growth of HeLa cell line by 50%
Effective concentration against cell growth of HeLa cell line by 50%
[PMID: 8759632]
HL-60 ED50
0.88 mM
Compound: AM
Effective concentration against cell growth of HL60 cell line by 50%
Effective concentration against cell growth of HL60 cell line by 50%
[PMID: 8759632]
HL-60 GI50
29 nM
Compound: AT, ametantrone
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 17962028]
HL60/MX2 GI50
430 nM
Compound: AT, ametantrone
Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay
[PMID: 17962028]
L1210 ED50
0.1 mM
Compound: AM
Effective concentration against cell growth of L1210 cell line by 50%
Effective concentration against cell growth of L1210 cell line by 50%
[PMID: 8759632]
L1210 EC50
1.77 μg/mL
Compound: 2
Effective concentration required to inhibit by 50% the growth of L1210 cells
Effective concentration required to inhibit by 50% the growth of L1210 cells
[PMID: 3172129]
L1210 EC50
275 nM
Compound: AME
Concentration of compound required to inhibit the cellular protein biosynthesis by 50%
Concentration of compound required to inhibit the cellular protein biosynthesis by 50%
[PMID: 8421288]
MCF7 IC50
0.51 μM
Compound: Ametantrone
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 28342691]
MCF7 IC50
0.51 μM
Compound: Ametantrone
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 27521587]
MCF7 GI50
4.97 μM
Compound: AT, ametantrone
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 17962028]
NCI-H460 GI50
2.55 μM
Compound: AT, ametantrone
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
[PMID: 17962028]
PC-3 GI50
8.52 μM
Compound: AT, ametantrone
Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
Cytotoxicity against human PC3 cells after 48 hrs by SRB assay
[PMID: 17962028]
SF-268 GI50
2.45 μM
Compound: AT, ametantrone
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
[PMID: 17962028]
分子量

412.48

Formula

C22H28N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ametantrone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ametantrone64862-96-0NSC 196473 NSC 290813NSC196473NSC-196473NSC290813NSC 290813NSC-290813DNA/RNA SynthesisDNA breakantitumor agentanthracenedioneDNA bindingInhibitorinhibitorinhibit

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目录号：
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