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  3. Aminopterin sodium

Aminopterin sodium  (Synonyms: 4-Aminofolic acid sodium; APGA sodium)

目录号: HY-14518A
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Aminopterin sodium (4-Aminofolic acid sodium)是一种抗肿瘤药物,具有免疫抑制活性。Aminopterin sodium通过抑制二氢叶酸还原酶的活性,阻断叶酸的代谢,从而影响核酸合成。Aminopterin sodium主要用于抑制急性淋巴细胞白血病和其他某些类型的癌症。Aminopterin sodium在临床上还用作免疫抑制剂,抑制自身免疫性疾病。

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Aminopterin sodium Chemical Structure

Aminopterin sodium Chemical Structure

CAS No. : 58602-66-7

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  • 生物活性

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  • 参考文献

生物活性

Aminopterin sodium (4-Aminofolic acid sodium) is an anti-tumor drug with immunosuppressive activity. Aminopterin sodium blocks the metabolism of folic acid by inhibiting the activity of dihydrofolate reductase, thereby affecting nucleic acid synthesis. Aminopterin sodium is mainly used to inhibit acute lymphoblastic leukemia and certain other types of cancer. Aminopterin sodium is also used clinically as an immunosuppressant to suppress autoimmune diseases[1].

分子量

484.38

Formula

C19H18N8Na2O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Aminopterin sodium
目录号:
HY-14518A
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