2. Epigenetics PI3K/Akt/mTOR
  3. AMPK
  4. AMPK activator 2

AMPK activator 2 (compound 7a) 是一种含氟氯胍衍生物，可上调 AMPK 信号通路并下调 mTOR/4EBP1/p70S6K。AMPK activator 2 抑制人类癌细胞系 (UMUC3、T24、A549) 的增殖和迁移。

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AMPK activator 2 Chemical Structure

AMPK activator 2 Chemical Structure

CAS No. : 2410961-69-0

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AMPK activator 2 相关抗体

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549)[1].

IC50 & Target[1]

AMPK

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
2.1 μM
Compound: 7a
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31864776]
A549 IC50
1.3 μM
Compound: 7a
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31864776]
HCT-116 IC50
3.5 μM
Compound: 7a
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31864776]
HUVEC IC50
8.5 μM
Compound: 7a
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31864776]
T-24 IC50
3.1 μM
Compound: 7a
Antiproliferative activity against human T24 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human T24 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31864776]
UMUC3 IC50
2 μM
Compound: 7a
Antiproliferative activity against human UM-UC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human UM-UC-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31864776]
分子量

301.31

Formula

C13H18F3N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AMPK activator 2 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMPK activator 22410961-69-0AMPK activator2AMPK activator-2AMPKAMP-activated protein kinasefluorine-containing proguanilmTOR4EBP1p70S6KproliferationmigrationUMUC3T24A549Inhibitorinhibitorinhibit

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AMPK activator 2
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HY-130723
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