2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. Androgen receptor antagonist 5

Androgen receptor antagonist 5 

目录号: HY-146494
产品使用指南

摩尔计算器

Androgen receptor antagonist 5 (compound 42f) 是一种有效的雄激素受体 (AR) 拮抗剂，IC50 为 6.17 μM。Androgen receptor antagonist 5 可有效损害 AR 核转位，降低细胞核 AR 水平，扰乱 AR 介导的基因调控。Androgen receptor antagonist 5 可抑制前列腺癌细胞 LNCaP 的增殖，并在 LNCaP 异种移植小鼠模型中表现出抗肿瘤活性。Androgen receptor antagonist 5 可用于前列腺癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Androgen receptor antagonist 5 Chemical Structure

Androgen receptor antagonist 5 Chemical Structure

CAS No. : 2586195-28-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Androgen receptor antagonist 5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer[1].

IC50 & Target

IC50: 6.17 μM (AR)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
94.3 μM
Compound: 42f
Antiproliferative activity against human DU-145 cells assessed as reduction in cel viability after 72 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as reduction in cel viability after 72 hrs by MTT assay
[PMID: 32169785]
LNCaP IC50
14.8 μM
Compound: 42f
Antiproliferative activity against human LNCaP cells assessed as reduction in cel viability after 72 hrs by MTT assay
Antiproliferative activity against human LNCaP cells assessed as reduction in cel viability after 72 hrs by MTT assay
[PMID: 32169785]
体外研究
(In Vitro)

Androgen receptor antagonist 5 has antiproliferative activity against LNCaP with an IC50 of 14.8 ± 0.57 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Androgen receptor antagonist 5 相关抗体:
分子量

493.43

Formula

C21H15F4N5O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Androgen receptor antagonist 5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Androgen receptor antagonist 52586195-28-8Androgen receptor antagonist5Androgen receptor antagonist-5Androgen ReceptorProstate cancerAnticancerAntitumorLNCaPInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Androgen receptor antagonist 5
目录号：
HY-146494
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z