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  4. Anemoside A3-methyl 6-aminohexanoate

Anemoside A3-methyl 6-aminohexanoate 

目录号: HY-161627
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Anemoside A3-methyl 6-aminohexanoate (Compound A3-6) 是 Pulchinenoside C (Anemoside B4) (HY-N0205) 的衍生物。Anemoside A3-methyl 6-aminohexanoate 抑制丙酮酸羧化酶 (pyruvate carboxylase，PC) (IC50 为 0.058 μM)，重新编程巨噬细胞功能，并通过抑制 NF-κB 和 NLRP3 炎症小体通路缓解 DSS 诱发的结肠炎。Anemoside A3-methyl 6-aminohexanoate 与 Anemoside B4 相比，表现出中等的体内药代动力学特征。

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Anemoside A3-methyl 6-aminohexanoate Chemical Structure

Anemoside A3-methyl 6-aminohexanoate Chemical Structure

CAS No. : 2919975-48-5

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Anemoside A3-methyl 6-aminohexanoate 相关抗体

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生物活性

Anemoside A3-methyl 6-aminohexanoate (Compound A3-6) is a derivative of Pulchinenoside C (Anemoside B4) (HY-N0205). Anemoside A3-methyl 6-aminohexanoate inhibits pyruvate carboxylase (PC) with an IC50 of 0.058 μM, reprograms macrophage function, and alleviates DSS-induced colitis through inhibition of the NF-κB and NLRP3 inflammasome pathway. Anemoside A3-methyl 6-aminohexanoate exhibits a moderate in vivo pharmacokinetic characters compared with Anemoside B4[1].

分子量

878.14

Formula

C48H79NO13
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anemoside A3-methyl 6-aminohexanoate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anemoside A3-methyl 6-aminohexanoate2919975-48-5NF-κBNuclear factor-κBNuclear factor-kappaBinflammatory bowel diseaseIBDcolitisICR mouseHepG2Inhibitorinhibitorinhibit

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