2. Apoptosis
  3. Apoptosis
  4. Angiogenesis inhibitor 2

Angiogenesis inhibitor 2 (compound 72) 是一种有效的血管生成 (angiogenesis) 抑制剂。Angiogenesis inhibitor 2 抑制 HUVEC 和 HCT-15 细胞的增殖，IC50 分别为 1.93 和 0.21 μM。Angiogenesis inhibitor 2 诱导 HUVEC 和 HCT-15 细胞凋亡 (apoptosis)。Angiogenesis inhibitor 2 具有抗癌活性，可抑制癌细胞的侵袭。Angiogenesis inhibitor 2 抑制斑马鱼胚胎血管生成。

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Angiogenesis inhibitor 2 Chemical Structure

Angiogenesis inhibitor 2 Chemical Structure

CAS No. : 2151067-32-0

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Angiogenesis inhibitor 2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Angiogenesis inhibitor 2 (compound 72) is a potent angiogenesis inhibitor. Angiogenesis inhibitor 2 inhibits the proliferation of HUVEC and HCT-15 cells, with IC50 values of 1.93 and 0.21 μM. Angiogenesis inhibitor 2 induces the apoptosis of HUVEC and HCT-15 cells. Angiogenesis inhibitor 2 shows anticancer activity, and suppresses the invasion of cancer cells. Angiogenesis inhibitor 2 inhibits the angiogenesis in zebrafish embryos[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEL IC50
4.22 μM
Compound: 4c
Cytotoxicity against human HEL cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HEL cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 29133049]
K562 IC50
3.19 μM
Compound: 4c
Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 29133049]
MDA-MB-231 IC50
5.57 μM
Compound: 4c
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 29133049]
PC-3 IC50
2.1 μM
Compound: 4c
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 29133049]
分子量

738.93

Formula

C42H50N4O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Angiogenesis inhibitor 2 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Angiogenesis inhibitor 22151067-32-0Angiogenesis inhibitor2Angiogenesis inhibitor-2ApoptosisHCT-15 cellsangiogenesisHUVECinvasionmigrationTetrandrine derivativesanti-metastaticanticancer activityInhibitorinhibitorinhibit

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