1. Anti-infection
  2. Filovirus
  3. Ansuvimab

Ansuvimab  (Synonyms: 安舒韦单抗; Ansuvimab-zyk; mAb114)

目录号: HY-P99337 纯度: 99.90%
COA

Ansuvimab (Ansuvimab-zyk) 是一种重组人单克隆 IgG1 抗体,对扎伊尔埃博拉病毒具有抗病毒活性。Ansuvimab 与扎伊尔埃博拉病毒上的糖蛋白结合,以阻止其进入宿主细胞。

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CAS No. : 2375952-29-5

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规格 价格 是否有货 数量
1 mg ¥3000
In-stock
5 mg ¥7500
In-stock
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50 mg   询价  

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查看 Filovirus 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus. Ansuvimab binds to the glycoprotein on Zaire ebolavirus to block its entry into host cells[1].

同型

Human IgG1 kappa

推荐同型对照抗体
IC50 & Target

ZEBOV

 

体外研究
(In Vitro)

Ansuvimab 通过结合位于埃博拉病毒糖蛋白 (GP) 的 GP1 亚基受体结合位点的 LEIKKPDGS 表位来阻断 GP 与 Niemann-Pick C1 受体之间的结合[1]
Ansuvimab 对转染 GP 的靶细胞具有抗体依赖性细胞毒性 (ADCC),在浓度为 0.03 μg/mL 时具有最大活性[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ansuvimab 给药使所有猕猴在第 0 天暴露于致死剂量的埃博拉病毒后存活下来[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

安舒韦单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Ansuvimab
目录号:
HY-P99337
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