2. NF-κB Stem Cell/Wnt JAK/STAT Signaling Immunology/Inflammation Apoptosis
  3. NF-κB STAT Interleukin Related TNF Receptor
  4. Anti-inflammatory agent 91

Anti-inflammatory agent 91 (Compound 4o) 是一种抗炎剂，可以通过抑制 STAT3 和 NF-κB 信号通路来减少炎性细胞因子。Anti-inflammatory agent 91 能用于改善银屑病的皮肤炎症的研究。

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Anti-inflammatory agent 91 Chemical Structure

Anti-inflammatory agent 91 Chemical Structure

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Anti-inflammatory agent 91 相关抗体

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  • 生物活性

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生物活性

Anti-inflammatory agent 91 (Compound 4o) is an anti-inflammatory agent that can reduce inflammatory cytokines by inhibiting the STAT3 and NF-κB signaling pathways. Anti-inflammatory agent 91 can be used in research to improve skin inflammation associated with psoriasis[1].

体外研究
(In Vitro)

Anti-inflammatory agent 91 (Compound 4o) (10-80 μM; 24 h) 对 HaCaT 细胞活力无显著影响[1]。
Anti-inflammatory agent 91 (10-40 μM; 2 h) 在 LPS (1 μg/mL; 24 h) 诱导的 RAW264.7 和 HaCaT 细胞中显著降低 NO (IC50= 19.5 μM)、TNF-α、IL-6 (RAW264.7) 和 IL-17A (HaCaT) 的水平，具有抗炎活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 91 相关抗体:
体内研究
(In Vivo)

Anti-inflammatory agent 91 (Compound 4o) (25-100 mg/kg; 局部涂抹，一天一次连续 5 天) 在咪喹莫特 (HY-B0180) 诱导的银屑病小鼠中可通过抑制炎性细胞因子来改善银屑病[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Imiquimod-induced Psoriasis mice model[1].
Dosage: 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration: Apply topically to skin once daily for 5 days. 12 hours after applying 5% imiquimod cream.
Result: Significantly inhibited the expression of inflammatory factors IL-6, IL-17A, IL-22, IL-23, and TNF-α in the serum of IMQ-induced psoriasis-like mice.
Significantly reduced the erythema and scales of the dorsal lesions of the mice compared to the imiquimod (IMQ) group.
Significantly reduced histopathological damage.
Effectively inhibited the expression of p65, STAT3, and p-STAT3, and slightly reduced the expression of p-p65.
分子量

507.89

Formula

C23H16ClF2NO6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献

Anti-inflammatory agent 91 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 91NF-κBSTATInterleukin RelatedTNF ReceptorNuclear factor-κBNuclear factor-kappaBILTumor Necrosis Factor ReceptorTNFRRAW264.7 cellPsoriasisBalb/c miceHaCaTInhibitorinhibitorinhibit

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