2. Anti-infection
  3. Bacterial
  4. Anti-MRSA agent 11

Anti-MRSA agent 11 对氟喹诺酮敏感菌株 USA500 和耐药 MRSA 菌株 Mu50 均表现出良好的活性，MIC 值为0.39 μg/mL。Anti-MRSA agent 11 具有良好的体内半衰期和安全性。

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Anti-MRSA agent 11 Chemical Structure

Anti-MRSA agent 11 Chemical Structure

CAS No. : 3029704-83-1

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Anti-MRSA agent 11 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-MRSA agent 11 suppresses fluoroquinolone-sensitive strain USA500 and -resistant MRSA isolate Mu50 (MIC =0.39 μg/mL). Anti-MRSA agent 11 displayes favorable in vivo half-life and safety profiles[1].

体外研究
(In Vitro)

Anti-MRSA agent 11 (100 μM；24 h) 对 A549 细胞和 HEK-293 细胞均无细胞毒性, Anti-MRSA agent 11 对细菌细胞具有高度选择性毒性[1]。
Anti-MRSA agent 11 (0.25 μg/ml；培养 15 代) 对 MRSA 菌株 ATCC33591 有持久的抗菌活性[1]。
Anti-MRSA agent 11 能够通过细菌的细胞膜，尤其是革兰氏阴性菌的外膜，进入细菌内部发挥作用[1]。
Anti-MRSA agent 11 抑制细菌的拓扑异构酶 IV ，从而干扰细菌的遗传物质传递过程[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-MRSA agent 11 相关抗体:
体内研究
(In Vivo)

Anti-MRSA agent 11 (0，400，1000 和 2000 mg/kg，灌胃；持续8天) 没有显著影响小鼠的体重和食物摄入量[1]。

药代动力学分析于雄性SD大鼠模型中[1]

Route Dose (mg/kg) AUCt (ng•h/mL) AUC0_INF (ng•h/mL) T1/2 (h) Tmax (h) Cmax (ng/mL) C0 (ng/mL) Cl (L•h/kg) MRT0_t (h) MRT0_INF (h) F (%)
i.v. 10 9060 9100 4.23 / / 11800 18.5 1.01 1.20 0.9
p.o. 20 162 171 2.16 2.67 31.0 / / 3.51 4.20 /

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (half male and half female, 7 weeks of age)
Dosage: 0,400, 1000 and 2000 mg/kg
Administration: i.g.
Result: Increased the body weight of mice in the administration groups gradually.
Showed no significant difference compared to those in the vehicle control group.
Sacrificed the mice, no damage to the main organs, including the brain, heart, liver, spleen, lung, and kidneys.
分子量

448.42

Formula

C24H18F2N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-MRSA agent 11 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-MRSA agent 113029704-83-1BacterialAnti-MRSA activitiesQuinolone-aminopyrimidine hybridsICR miceSD ratsInhibitorinhibitorinhibit

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