2. NF-κB MAPK/ERK Pathway
  3. RANKL/RANK p38 MAPK NF-κB
  4. Anti-osteoporosis agent-8

Anti-osteoporosis agent-8 (Compound 4aa) 是 RANKL 抑制剂，可抑制 RANKL 诱导的破骨细胞生成和破骨细胞分化，IC50 为 2.41 μM。Anti-osteoporosis agent-8 可改善卵巢切除 (OVX) 小鼠模型中的骨质流失。

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Anti-osteoporosis agent-8 Chemical Structure

Anti-osteoporosis agent-8 Chemical Structure

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Anti-osteoporosis agent-8 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for RANKL, which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation (IC50 is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model[1].

体外研究
(In Vitro)

Anti-osteoporosis agent-8 (0-10 μM，5 天) 通过激活 BMP2 信号通路促进 MC3T3-E1 细胞中的成骨细胞分化[1].
Anti-osteoporosis agent-8 (5 μM，6 h) 通过抑制 MAPK 和 NF-κB 信号通路，抑制破骨细胞相关基因的表达、破骨细胞生成和破骨细胞骨吸收[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-osteoporosis agent-8 相关抗体:

Western Blot Analysis[1]

Cell Line: BMMS
Concentration: 5 μM
Incubation Time: 6 h
Result: Inhibited phosphorylation of p38, ERK, JNK, p65 and IκBα.

Real Time qPCR[1]

Cell Line: MC3T3-E1
Concentration: 0-10 μM
Incubation Time: 5 days
Result: Promoted expression of BMP2, Runx2 and Smad.
体内研究
(In Vivo)

Anti-osteoporosis agent-8 (10 mg/kg，腹腔注射，每 2 天一次，持续 8 周) 可预防 C57BL/6 小鼠模型中卵巢切除引起的骨质流失[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ovariectomized C57BL/6 mice model[1]
Dosage: 10 mg/kg
Administration: i.p., every other days, for 8 weeks
Result: Reduced the bone loss, increased bone volume/total bone volume, trabecular thickness and trabecular number, without significant toxicity in mainly organs.
分子量

431.31

Formula

C18H19F3N2O2Se
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-osteoporosis agent-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-osteoporosis agent-8RANKL/RANKp38 MAPKNF-κBNuclear factor-κBNuclear factor-kappaBRAW264.7C57BL/6 miceMC3T3-E1BMMSInhibitorinhibitorinhibit

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