2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 106

Antibacterial agent 106 (化合物 8) 是一种口服有效的具有抗菌膜活性的抗菌剂。Antibacterial agent 106 对多重耐药 (MDR) 革兰氏阳性病原菌具有较强的抗菌作用。Antibacterial agent 106 能有效清除巨噬细胞内 99.7% 的耐甲氧西林金黄色葡萄球菌 (MRSA)。

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Antibacterial agent 106 Chemical Structure

Antibacterial agent 106 Chemical Structure

CAS No. : 2459657-11-3

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Antibacterial agent 106 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 106 (compound 8) is an orally active and potent antibacterial agent with antibiofilm activity. Antibacterial agent 106 shows potent antibacterial effect against multi-agent resistant (MDR)-Gram positive pathogens. Antibacterial agent 106 is highly effective in clearing 99.7% of the intracellular methicillin-resistant S. aureus (MRSA) harbored inside macrophages[1]. Antibacterial agent 106 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Caco-2 CC50
> 128 μg/mL
Compound: 8
Cytotoxicity against human Caco2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human Caco2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 31718945]
体内研究
(In Vivo)

Antibacterial agent 106 (compound 8) can penetrate gut cells and reach plasma within 15 min and maintain effective plasma concentration for around 12 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

380.51

Formula

C20H24N6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 106 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 1062459657-11-3Antibacterial agent106Antibacterial agent-106Bacterialorally activeMDR-BacteriaAntibiotic resistanceMRSAStaphylococcal infectionsAntibiofilmIntracellular infectionsInhibitorinhibitorinhibit

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