2. Anti-infection
  3. Bacterial Antibiotic
  4. Antibacterial agent 128

Antibacterial agent 128 是一种带有可裂解接头的铁载体类似物-环丙沙星 (Ciprofloxacin (Ciprofloxacin (HY-B0356))) 偶联物。Antibacterial agent 128 显示出针对铜绿假单胞菌 (MIC 值为 0.25-64 μg/mL) 和类鼻疽伯克氏菌 (MIC 值为 1-32 μg/mL) 的抗生素活性。

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Antibacterial agent 128 Chemical Structure

Antibacterial agent 128 Chemical Structure

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Antibacterial agent 128 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 128 is a siderophore analog-Ciprofloxacin (Ciprofloxacin (HY-B0356)) conjugate with a cleavable linker. Antibacterial agent 128 shows antibiotic activities against P. aeruginosa (MIC values of 0.25-64 μg/mL) and B. pseudomallei (MIC values of 1-32 μg/mL)[1].

IC50 & Target

MIC: 0.25-64 μg/mL (P. aeruginosa), 1-32 μg/mL (B. pseudomallei), 4-128 μg/mL (B. thailandensis)[1]
体外研究
(In Vitro)

Antibacterial agent 128 (compound 2d)，带有一个带有可裂解接头的羟基吡啶酮部分，对铜绿假单胞菌 (P. aeruginosa) (MIC = 0.25-64 μg/mL)、类鼻疽伯克氏菌 (B. pseudomallei) (MIC = 1-32 μg/ mL) 和泰国伯克霍尔德氏菌 (B. thailandensis) (MIC = 4-128 μg/mL)。 此外，Antibacterial agent 128 对铜绿假单胞菌环丙沙星耐药菌株 AM85 有活性，且无细胞毒性[1]。
使用铁转运系统是一种很有前途的策略，可以绕过细菌细胞膜并恢复传统抗生素（如环丙沙星）的活性。铁载体类似物对应于假单胞菌属和伯克霍尔德氏菌属识别的单邻苯二酚或羟基吡啶酮部分。物理化学研究表明 (i) 结合物不能通过被动扩散相互作用或穿过膜，以及 (ii) 带有可裂解接头的结合物在生理环境中是稳定的[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 128 相关抗体:
分子量

556.50

Formula

C26H25FN4O9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 128 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 128Antibacterial agent128Antibacterial agent-128BacterialAntibioticantibiotic activitiesPseudomonas aeruginosaBurkholderia spp.Ciprofloxaciniron transport systemGram-negative bacteriaInhibitorinhibitorinhibit

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Antibacterial agent 128
目录号：
HY-151944
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