2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 106

Anticancer agent 106 (化合物 10ic) 是一种抗癌剂，可诱导 B16-F10 黑色素瘤细胞凋亡 (apoptosis)。Anticancer agent 106 还能有效抑制肺转移性黑色素瘤小鼠模型中的转移性结节。Anticancer agent 106 可用于癌症，尤其是肺转移性黑色素瘤的研究。

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Anticancer agent 106 Chemical Structure

Anticancer agent 106 Chemical Structure

CAS No. : 3009090-13-2

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Anticancer agent 106 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 106 (compound 10ic) is an anticancer agent that induces apoptosis in B16-F10 melanoma cells. Anticancer agent 106 also potently inhibits metastatic nodules in a mouse model of lung metastatic melanoma. Anticancer agent 106 can be used in the study of cancer, especially lung metastatic melanoma[1].

体外研究
(In Vitro)

Anticancer agent 106 (化合物 10ic; 0.28-55 μM; 24 h) 以剂量依赖性方式降低 B16-F10 黑色素瘤细胞的活力，IC50 值为 4.8 μM[1]。
Anticancer agent 106 (5-20 μM; 48 h) 诱导 B16-F10 黑色素瘤细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 106 相关抗体:

Cell Viability Assay[1]

Cell Line: B16-F10 melanoma cells
Concentration: 0.28-55 μM
Incubation Time: 24 h
Result: Inhibited B16-F10 melanoma cells in a dose-dependent manner (IC50 = 4.8 μM).

Apoptosis Analysis[1]

Cell Line: B16-F10 melanoma cells
Concentration: 5-20 μM
Incubation Time: 48 h
Result: Induced cell apoptosis.
体内研究
(In Vivo)

Anticancer agent 106 (9-9.5 mg/kg; i.p.; every 3rd d for 22 d) 抑制肺转移性黑色素瘤小鼠模型中的转移性结节[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16-F10 melanoma-bearing C57BL/6 mice (pulmonary metastatic melanoma model)[1].
Dosage: 9-9.5 mg/kg
Administration: Intraperitoneal administration; every 3rd d for 22 d.
Result: Inhibited the lung metastases.
分子量

475.56

Formula

C26H25N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 106 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 1063009090-13-2Anticancer agent106Anticancer agent-106Apoptosiscancerlung metastatic melanomamelanomaB16-F10 cellsInhibitorinhibitorinhibit

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