2. Anti-infection Apoptosis
  3. Bacterial Apoptosis Necroptosis
  4. Anticancer agent 118

Anticancer agent 118 是一种 N- 酰化环丙沙星衍生物，具有抗菌 (bacterial) 和抗癌活性。Anticancer agent 118 显示出对革兰氏阳性菌株的高活性和对前列腺癌 PC3 细胞的抗增殖活性，可用于抗肿瘤研究。

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Anticancer agent 118 Chemical Structure

Anticancer agent 118 Chemical Structure

CAS No. : 864443-43-6

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Anticancer agent 118 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 118, a N‑acylated ciprofloxacin derivative, has anti-bacterial and anticancer activities. Anticancer agent 118 shows high activity against Gram-positive strains and antiproliferative activities against prostate PC3 cells. Anticancer agent 118 can be used for antitumor research[1].

体外研究
(In Vitro)

Anticancer agent 118 (Compound 3) (0-100 μM；72 小时) 显示对前列腺癌 PC3 细胞的高度抗增殖活性，以及诱导 PC3 细胞凋亡/坏死[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 118 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Prostate PC3 and HaCaT cells
Concentration: 0-100 μΜ
Incubation Time: 72 hours
Result: Showed high antiproliferative activities against prostate PC3 cells with an IC50 of 2.02 μM.
Reduced the growth and proliferation rates in prostate PC3cells, without acytotoxic action against normal HaCaT cell lines.
Induced apoptosis/necrosis in PC3 cells by increasing the intracellular ROS amount and diminished the IL-6 level in tumor cells.
分子量

407.82

Formula

C19H19ClFN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 118 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 118864443-43-6Anticancer agent118Anticancer agent-118BacterialApoptosisNecroptosisAntibacterialanticancerPC3HaCaT cellsGram-positive strainsInhibitorinhibitorinhibit

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