2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Anticancer agent 225

Anticancer agent 225 (Comp 51) 是一种三萜酸类似物，可抑制不同类型的肿瘤干细胞 (CSCs)，并增加 CSCs 的 ROS 水平。Anticancer agent 225 可用于肿瘤研究。

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Anticancer agent 225 Chemical Structure

Anticancer agent 225 Chemical Structure

CAS No. : 2251753-61-2

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规格 价格 是否有货 数量
500 μg ￥2880
3 - 4 周
1 mg ￥4950
3 - 4 周
5 mg   询价  
10 mg   询价  

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Anticancer agent 225 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 225 (Comp 51) is a triterpenoic acids analogue which exhibits suppressive effect on elimination of different type of cancer stem cells (CSCs) and increase the ROS level of CSCs. Anticancer agent 225 can be used for cancer research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
1.536 μM
Compound: 51
Cytotoxicity activity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
A-375 IC50
0.8274 μM
Compound: 51
Cytotoxicity activity against human A375 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human A375 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
A-375 IC50
2.4 μM
Compound: 51
Cytotoxicity against human A375 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
Cytotoxicity against human A375 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
[PMID: 30433783]
A549 IC50
9.891 μM
Compound: 51
Cytotoxicity activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
B16-F10 IC50
1.084 μM
Compound: 51
Cytotoxicity activity against mouse B16F10 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against mouse B16F10 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
B16-F10 IC50
1.59 μM
Compound: 51
Cytotoxicity against mouse B16F10 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
Cytotoxicity against mouse B16F10 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
[PMID: 30433783]
Lewis lung carcinoma cell line IC50
1.022 μM
Compound: 51
Cytotoxicity activity against mouse LLC cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against mouse LLC cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
MDA-MB-231 IC50
5.582 μM
Compound: 51
Cytotoxicity activity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
PANC-1 IC50
1.24 μM
Compound: 51
Cytotoxicity activity against human PANC1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human PANC1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
体外研究
(In Vitro)

Anticancer agent 225 对 A375 和 B16F10 细胞的 IC50 分别为 2.4 和 1.59 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 225 相关抗体:
体内研究
(In Vivo)

Anticancer agent 225 (5 mg/kg, 腹腔注射, 每日一次共 15 d) 对 C57BL/6 和 Balb/C 裸鼠的肿瘤生长有抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

673.99

Formula

C41H59N3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 225 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 2252251753-61-2Anticancer agent225Anticancer agent-225Reactive Oxygen SpeciestriterpenoicROSCSCscancerInhibitorinhibitorinhibit

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