2. Apoptosis Autophagy
  3. Apoptosis Mitophagy
  4. Anticancer agent 227

Anticancer agent 227 (compound YNU-1c) 是一种强效抗癌剂。Anticancer agent 227 具有抗增殖活性。Anticancer agent 227 可诱导细胞凋亡 (apoptosis) 和线粒体自噬 (mitophagy)。

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Anticancer agent 227 Chemical Structure

Anticancer agent 227 Chemical Structure

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Anticancer agent 227 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 227 (compound YNU-1c) is a potent anticancer agent. Anticancer agent 227 shows antiproliferative activity. Anticancer agent 227 induces apoptosis and mitophagy[1].

体外研究
(In Vitro)

Anticancer agent 227 (compound YNU-1c) (0-50 µM; 48 h) 显示出抗增殖活性，对 HepG2、HCC1806、HL-7702 细胞的 IC50 值分别为 0.19、0.13、>50 µM[1]。
Anticancer agent 227 (0.13 µM; 48 h) 通过增加细胞色素 c 和裂解 caspase-3 的表达来诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 227 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HepG2, HCC1806, HL-7702, SF1, SF2 cells
Concentration: 0-50 μM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50s of 0.19, 0.13, >50, >384.6, >263.2 μM for HepG2, HCC1806, HL-7702, SF1, SF2 cells, respectively.

Western Blot Analysis[1]

Cell Line: HCC1806 cells
Concentration: 0.13 µM
Incubation Time: 48 h
Result: Upregulated the expression of cytochrome c and cleaved caspase-3.
体内研究
(In Vivo)

Anticancer agent 227 (5 mg/kg; i.p.; every 2 days for 21 days) 在 HCC1806 荷瘤裸鼠中显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice (HCC1806 cells)[1]
Dosage: 5 mg/kg
Administration: I.p.; every 2 days for 21 days
Result: Effectively inhibited HCC1806 tumor growth, reduced tumor weight with a tumor growth inhibition rate of 58.9 %.
分子量

854.78

Formula

C38H27Cl5N2O2PRh
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 227 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 227Anticancer agent227Anticancer agent-227ApoptosisMitophagyMitochondrial Autophagyantiproliferativeanticancer agentapoptosismitophagyHCC1806 cellsInhibitorinhibitorinhibit

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