2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. Anticancer agent 231

Anticancer agent 231 (化合物 P5) 是一种酪氨酸蛋白激酶抑制剂，IC50 值为 3.95 μM。Anticancer agent 231 通过靶向 EGFR-ERK1/2 信号通路抑制三阴乳腺癌 (TNBC) 细胞的细胞活力、细胞增殖、细胞迁移和癌症干性，有望在 TNBC 疾病治疗领域发挥重要作用。

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Anticancer agent 231 Chemical Structure

Anticancer agent 231 Chemical Structure

CAS No. : 128519-30-2

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Anticancer agent 231 相关抗体

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 231 (Compound P5) is a tyrosine protein kinase inhibitor with a IC50 value of 3.95 μM. Anticancer agent 231 inhibits the cell viability, cell proliferation, cell migration and cancer dryness of triple negative breast cancer (TNBC) cells by targeting EGFR-ERK 1/2 signaling pathway, and is expected to play an important role in the field of TNBC disease therapy[1].
IC50 & Target

ERK1

 

ERK2

 

体外研究
(In Vitro)

Anticancer agent 231 (化合物 P5) 具有良好的细胞毒性并抑制 TNBC 细胞的生存能力[1]。
Anticancer agent 231 (化合物 P5) (1, 2, 4 μM, 14 天; 1, 2, 4 μM, 8 天) 减弱 Hs578T 细胞和 MDA MB 231 细胞的增殖能力[1]。
Anticancer agent 231 (化合物 P5) (1, 2, 4 μM, 12 h) 减弱 Hs578T 细胞的迁移能力[1]。
Anticancer agent 231 (化合物 P5) (1, 2 μM) 抑制肿瘤干性并增强 TNBC 细胞对紫杉醇的敏感性[1]。
Anticancer agent 231 (化合物 P5) (1, 2, 4 μM; 5, 10, 20 μM)通过靶向 EGFR-ERK 1/2 轴来抑制 TNBC 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 231 相关抗体:

Cell Line:
Concentration:
Incubation Time:
Result:

Cell Viability Assay[1].

Cell Line: Hs578T cell, MDA MB 231 cell
Concentration: 0-40 μM
Incubation Time: 48 h
Result: Exhibited the most cytotoxic effect against Hs578T cells and MDA MB 231 cells

Cell Proliferation Assay[1].

Cell Line: Hs578T cell
Concentration: 1, 2, 4 μM
Incubation Time: 14 days
Result: Inhibited the colony formation of Hs578T cells

Cell Proliferation Assay[1].

Cell Line: MDA MB 231 cell
Concentration: 5, 10, 20 μM
Incubation Time: 8 days
Result: Inhibited the colony formation of MDA MB 231 cells

Cell Migration Assay [1].

Cell Line: Hs578T cell
Concentration: 1, 2, 4 μM
Incubation Time: 12 h
Result: Inhibited the migration ability of Hs578T cells

Western Blot Analysis[1].

Cell Line: Hs578T cell, MDA MB 231 cell
Concentration: 1, 2, 4 μM; 5, 10, 20 μM
Incubation Time: 48 h
Result: Reduced the EGFR expression level in Hs578T and MDA MB 231 cells and deactivated the EGFR in MDA MB 231 cells
分子量

375.89

Formula

C23H22ClN3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 231 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 231128519-30-2Anticancer agent231Anticancer agent-231ERKExtracellular signal regulated kinasesN-phenyl pyrazolineTNBCHs578T cellMDA MB 231 cellInhibitorinhibitorinhibit

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