2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 32

Anticancer agent 32 (compound 2g) 是一种抗癌剂。Anticancer agent 32 具有抗癌活性，影响细胞周期并诱导细胞凋亡。Anticancer agent 32 可以用于癌症的研究。

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Anticancer agent 32 Chemical Structure

Anticancer agent 32 Chemical Structure

CAS No. : 2222930-76-7

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Anticancer agent 32 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 32 (compound 2g) is an anticancer agent. Anticancer agent 32 shows anticancer activities, affects cell cycle and induces cell apoptosis. Anticancer agent 32 can be used for the research of cancer[1].

IC50 & Target

IC50: 17.2 μM (MGC-803), 12.3 μM (HeLa), 40.6 μM (NCI-H460), 46.8 μM (HepG2), 95.4 μM (SMMC-7721), 8.9 μM (T-24), 86.8 μM (HL-7702)[1]
体外研究
(In Vitro)

Anticancer agent 32 (2.5-40 μM; 48 h) shows cytotoxic activities to cancer cell lines[1].
Anticancer agent 32 (0-16 μM; 24 h) affects cell cycle, induces cell apoptosis, increases intracellular levels of Ca2+ and ROS[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 32 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cell lines
Concentration: 2.5, 5, 10, 20 and 40 μM
Incubation Time: 48 hours
Result: Inhibited cell growth with IC50 values of 17.2, 12.3, 40.6, 46.8, 95.4, 8.9 and 86.8 μM for MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MGC-803 and T-24 cell lines
Concentration: 0, 8 and 12 μM
Incubation Time: 24 hours
Result: Significantly induced cell cycle arrest at the G2/M phase in T-24 cells.

Western Blot Analysis[1]

Cell Line: MGC-803 and T-24 cell lines
Concentration: 4, 8 and 12 μM
Incubation Time: 24 hours
Result: Decreased expression level of cyclin B1.

Apoptosis Analysis[1]

Cell Line: MGC-803 and T-24 cell lines
Concentration: 0, 4, 8 and 16 μM
Incubation Time: 24 hours
Result: Induced cell apoptosis of T-24 cells from 8.21 to 32.91% after treatment by increasing levels of caspase-3 and caspase-9 in T-24 cells.
分子量

433.45

Formula

C24H21F2N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 32 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 322222930-76-7Anticancer agent32Anticancer agent-32ApoptosisquinoxalinesorafenibchemotherapyanticancerMGC-803HeLaNCI-H460apoptosiscell cycleROSInhibitorinhibitorinhibit

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