2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 39

Anticancer agent 39 (compound B12) 是济源冬凌草素 A (JOA) 的荧光衍生物，可诱导线粒体膜电位 (MMP) 的崩溃，从而诱导细胞凋亡。Anticancer agent 39 抑制细胞克隆和迁移。Anticancer agent 39 具有抗 HGC-27 细胞增殖活性 IC50 值为 0.39 μM。

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Anticancer agent 39 Chemical Structure

Anticancer agent 39 Chemical Structure

CAS No. : 2762426-00-4

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Anticancer agent 39 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 39 (compound B12), a fluorescent derivative of Jiyuan Oridonin A (JOA), induces the collapse of mitochondrial membrane potential (MMP)and thus induced apoptosis.Anticancer agent 39 inhibits cell cloning and migration.Anticancer agent 39 exhibits promising anti-proliferative activity against HGC-27 cells with IC50 value of 0.39 μM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HGC-27 IC50
3.11 μM
Compound: B6
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
[PMID: 34954589]
MGC-803 IC50
2.18 μM
Compound: B6
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
[PMID: 34954589]
PC-3 IC50
0.81 μM
Compound: B6
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
[PMID: 34954589]
SW1990 IC50
1.64 μM
Compound: B6
Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
[PMID: 34954589]
TE-1 IC50
1.44 μM
Compound: B6
Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
[PMID: 34954589]
分子量

896.08

Formula

C50H65N5O10
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 39 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 392762426-00-4Anticancer agent39Anticancer agent-39ApoptosisJiyuan?Oridonin?Amitochondrial membrane potentialMMPcloningmigrationproliferative activityHGC-27Inhibitorinhibitorinhibit

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