2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 47

Anticancer agent 47 (compound 4j) 是一种有效的抗癌剂。Anticancer agent 47 显示出抗增殖活性。Anticancer agent 47 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G0/G1 期。Anticancer agent 47 在体内显示出抗肿瘤活性。

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Anticancer agent 47 Chemical Structure

Anticancer agent 47 Chemical Structure

CAS No. : 2461795-23-1

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Anticancer agent 47 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 47 (compound 4j) is a potent anticancer agent. Anticancer agent 47 shows antiproliferative activities. Anticancer agent 47 induces apoptosis and cell cycle arrest at G0/G1 phase. Anticancer agent 47 shows shows antitumor activities in vivo[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.72 μM
Compound: 4j
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
[PMID: 32682198]
A549 IC50
4.55 μM
Compound: 4j
Antiproliferative activity against human A549 cells measured after 48 hrs in presence of NQO1 inhibitor dicoumarol by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs in presence of NQO1 inhibitor dicoumarol by MTT assay
[PMID: 32682198]
HepG2 IC50
1.6 μM
Compound: 4j
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
[PMID: 32682198]
L02 IC50
20.98 μM
Compound: 4j
Cytotoxicity against human L02 cells measured after 48 hrs by MTT assay
Cytotoxicity against human L02 cells measured after 48 hrs by MTT assay
[PMID: 32682198]
NCI-H596 IC50
7.07 μM
Compound: 4j
Antiproliferative activity against human NCI-H596 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human NCI-H596 cells measured after 48 hrs by MTT assay
[PMID: 32682198]
体外研究
(In Vitro)

Anticancer agent 47 (compound 4j) shows antiproliferative activities with IC50s of 1.6, 0.72, 7.07 µM for HepG2, A549, H596 cells, respectively[1].
Anticancer agent 47 (0.8, 1.6, 3.2 µM; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase[1].
Anticancer agent 47 (5 µM; 5h) significantly increases ROS production[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 47 相关抗体:

Apoptosis Analysis[1]

Cell Line: HepG2, H596 cells
Concentration: 0.8, 1.6, 3.2 µM
Incubation Time: 24 h
Result: Induced apoptosis with the apoptotic cell rates were 14.23, 20.47 and 27.66% at 0.8, 1.6, 3.2 µM in HepG2 cell, respectively.

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 0.8, 1.6, 3.2 µM
Incubation Time: 24 h
Result: Showed 48.54%, 49.60% and 53.00% cells were at G0/G1 phase at 0.6, 1.2 and 2.4 µM, respectively.
体内研究
(In Vivo)

Anticancer agent 47 (20 mg/kg; i.v.; once every 2 days for 19 days) shows antitumor activities[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (HepG2 xenografts)[1]
Dosage: 20 mg/kg
Administration: I.v.; once every 2 days for 19 days
Result: Effectively inhibited tumor growth with the 58.7% tumor inhibition rate.
分子量

366.39

Formula

C19H14N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 47 相关分类

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质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 472461795-23-1Anticancer agent47Anticancer agent-47ApoptosisantitumorHepG2 cellsROS productionapoptosisG0/G1 phaseHepG2 xenograftsInhibitorinhibitorinhibit

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