2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Anticancer agent 48

Anticancer agent 48 (compound 48) 是一种广谱抗癌剂。Anticancer agent 48 抑制微管蛋白聚合。Anticancer agent 48 表现出抗增殖活性。Anticancer agent 48 在体内显示抗肿瘤活性。Anticancer agent 48 具有研究实体瘤和血液肿瘤的潜力。

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Anticancer agent 48 Chemical Structure

Anticancer agent 48 Chemical Structure

CAS No. : 2395009-13-7

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Anticancer agent 48 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
27 nM
Compound: 48
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31727471]
HT-29 IC50
51 nM
Compound: 48
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31727471]
KBM5 IC50
14 nM
Compound: 48
Cytotoxicity against human KBM5 cells expressing IM- sensitive wild type Bcr/Abl assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human KBM5 cells expressing IM- sensitive wild type Bcr/Abl assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31727471]
KBM5 IC50
16 nM
Compound: 48
Cytotoxicity against human KBM5 cells expressing IM-resistant Bcr/Abl T315I mutant assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human KBM5 cells expressing IM-resistant Bcr/Abl T315I mutant assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31727471]
KU812 cell line IC50
8 nM
Compound: 48
Cytotoxicity against human KU812 cells expressing IM- sensitive wild type Bcr/Abl assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human KU812 cells expressing IM- sensitive wild type Bcr/Abl assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31727471]
MCF7 IC50
14 nM
Compound: 48
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 96 hrs by MTT assay
[PMID: 31727471]
MCF7 IC50
14 nM
Compound: 1
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 96 hrs
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 96 hrs
[PMID: 34052717]
SW480 IC50
48 nM
Compound: 48
Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31727471]
SW-620 IC50
28 nM
Compound: 48
Cytotoxicity against human SW620 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SW620 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31727471]
T-24 IC50
12 nM
Compound: 48
Cytotoxicity against human T24 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human T24 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 31727471]
T98G IC50
36.6 nM
Compound: 48
Cytotoxicity against human T98G cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human T98G cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 31727471]
U-87MG ATCC IC50
30.9 nM
Compound: 48
Cytotoxicity against human U87MG cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human U87MG cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 31727471]
体外研究
(In Vitro)

Anticancer agent 48 (compound 48) inhibits tubulin polymerization and MCF-7 cancer cell growth with IC50s of 0.47 µM and 14 nM, respectively[1].
Anticancer agent 48 shows antiproliferative activity with IC50s of 8, 10, 12, 14, 16 nM for KU812, LAMA84-S, LAMA84-R, KBM5-WT, KBM5-T315I cells, respectively[1].
Anticancer agent 48 shows growth inhibition with IC50s of 12, 31, 37, 221, 56, 27, 51, 48, 28, 12 nM for U343G, U87MG, T98G, SK-N-BE, SK-N-BE(2)-C, HT29, HCT116, SW480, SW620, T24 cell, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 48 相关抗体:
体内研究
(In Vivo)

Anticancer agent 48 (20 mg/kg; i.p.; every 2 days for 40 days) shows antitumor effects[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8 week-old female BALB/Cnu/nu mice (EZ-2 or T24 cells)[1]
Dosage: 20 mg/kg
Administration: I.p.; every 2 days for 40 days
Result: Significantly inhibited cancer cell proliferation, in vivo tumorigenesis, and tumor angiogenesis.
分子量

443.49

Formula

C26H25N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 48 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 482395009-13-7Anticancer agent48Anticancer agent-48Microtubule/Tubulinantiproliferativeubulin polymerizationglioblastomacolorectalurinary bladder cancerantitumorInhibitorinhibitorinhibit

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