2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Anticancer agent 48

Anticancer agent 48 (compound 48) 是一种广谱抗癌剂。Anticancer agent 48 抑制微管蛋白聚合。Anticancer agent 48 表现出抗增殖活性。Anticancer agent 48 在体内显示抗肿瘤活性。Anticancer agent 48 具有研究实体瘤和血液肿瘤的潜力。

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Anticancer agent 48 Chemical Structure

Anticancer agent 48 Chemical Structure

CAS No. : 2395009-13-7

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Anticancer agent 48 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors[1].

体外研究
(In Vitro)

Anticancer agent 48 (compound 48) inhibits tubulin polymerization and MCF-7 cancer cell growth with IC50s of 0.47 µM and 14 nM, respectively[1].
Anticancer agent 48 shows antiproliferative activity with IC50s of 8, 10, 12, 14, 16 nM for KU812, LAMA84-S, LAMA84-R, KBM5-WT, KBM5-T315I cells, respectively[1].
Anticancer agent 48 shows growth inhibition with IC50s of 12, 31, 37, 221, 56, 27, 51, 48, 28, 12 nM for U343G, U87MG, T98G, SK-N-BE, SK-N-BE(2)-C, HT29, HCT116, SW480, SW620, T24 cell, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 48 相关抗体:
体内研究
(In Vivo)

Anticancer agent 48 (20 mg/kg; i.p.; every 2 days for 40 days) shows antitumor effects[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8 week-old female BALB/Cnu/nu mice (EZ-2 or T24 cells)[1]
Dosage: 20 mg/kg
Administration: I.p.; every 2 days for 40 days
Result: Significantly inhibited cancer cell proliferation, in vivo tumorigenesis, and tumor angiogenesis.
分子量

443.49

Formula

C26H25N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 48 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 482395009-13-7Anticancer agent48Anticancer agent-48Microtubule/Tubulinantiproliferativeubulin polymerizationglioblastomacolorectalurinary bladder cancerantitumorInhibitorinhibitorinhibit

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