2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 53

Anticancer agent 53 是一种强效抗癌剂。 Anticancer agent 53 显示出体外细胞毒性。Anticancer agent 53 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 S/G2/M 期。Anticancer agent 53 具有抗肿瘤活性且无明显毒性。

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Anticancer agent 53 Chemical Structure

Anticancer agent 53 Chemical Structure

CAS No. : 1926985-18-3

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Anticancer agent 53 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 53 is a potent anticancer agent. Anticancer agent 53 shows in vitro cytotoxicity. Anticancer agent 53 induces apoptosis and cell cycle arrest in S/G2/M phases. Anticancer agent 53 shows antitumor activity with no apparent toxicity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
4.3 nM
Compound: c20
Cytotoxicity against human A549 cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 31881457]
Hep 3B2 IC50
2.3 nM
Compound: c20
Cytotoxicity against human Hep3B cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human Hep3B cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 31881457]
KB IC50
24 nM
Compound: c20
Cytotoxicity against human KB cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human KB cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 31881457]
MCF7 IC50
42 nM
Compound: c20
Cytotoxicity against human MCF7 cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 31881457]
MDA-MB-231 IC50
96.3 nM
Compound: c20
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 31881457]
体外研究
(In Vitro)

Anticancer agent 53 (compound c20) (0-1000 nM; 72 h) shows cytotoxicity with IC50s of 2.3, 42.0, 4.3, 96.3, 24.0, 47.4 nM for Hep3B, MCF7, A549, MDA-MB-231, KB, KB-vin cells, respectively[1].
Anticancer agent 53 (0.025, 0.05, 0.1 µM; 48 h) induces apoptosis and cell cycle arrest in S/G2/M phases[1].
Anticancer agent 53 (0.1. 0.2 µM; 6 h) inhibits topoisomerase I activity in A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 53 相关抗体:

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 0.025, 0.05, 0.1 µM
Incubation Time: 0-48 h
Result: Induced cell cycle arrest in S/G2/M phases.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 0.025, 0.05, 0.1 µM
Incubation Time: 0-48 h
Result: Induced apoptosis with the proapoptotic protein Caspase-3 and Bax were up-regulated and anti-apoptotic Bcl-2 was down-regulated.
体内研究
(In Vivo)

Anticancer agent 53 (5, 25 and 50 mg/kg; IP) shows no apparent toxicity to mouse liver, kidney and hemopoietic system[1].
Anticancer agent 53 (2 mg/kg; i.v; every other day for two weeks) shows antitumor effect in HCC mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/C mice[1]
Dosage: 5, 25 and 50 mg/kg (saline with 5% DMSO and 5% Cremophor EL)
Administration: I.p.
Result: Showed no body weight loss, no significant liver damage, no significant damage occurred in spleens and livers.
Animal Model: 6-8 weeks Female BALB/c nude mice (Hep3B cells)[1]
Dosage: 1, 2 mg/kg
Administration: I.v., every other day for total 7 doses
Result: Significantly inhibited tumor growth with an average body weight of 24 g and an average tumor volume of 3800 mm[3] at 1 mg/kg and an average body weight of 22 g and average tumor volume 2380 mm[3] at 2 mg/kg.
Animal Model: 6-8 weeks FVB/N mice (HCC mouse model)[1]
Dosage: 2 mg/kg
Administration: I.v.; every other day for two weeks
Result: Inhibited the tumor growth and reduced the liver weights, and t inhibited proliferation of HCC tissues.
分子量

600.62

Formula

C31H25FN4O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 53 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 531926985-18-3Anticancer agent53Anticancer agent-53ApoptosisanticancerapoptosisA549 cellscytotoxicityHCC mouse modelS/G2/MHep3B cellsInhibitorinhibitorinhibit

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