2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 54

Anticancer agent 54 是一种有效的抗癌剂。Anticancer agent 54 显示出抗增殖活性。 Anticancer agent 54 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G0/G1 期。Anticancer agent 54 的抗癌活性取决于 DNA 嵌入和 ROS 生成。

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Anticancer agent 54 Chemical Structure

Anticancer agent 54 Chemical Structure

CAS No. : 2933882-99-4

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Anticancer agent 54 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation[1].

体外研究
(In Vitro)

Anticancer agent 54 (compound L) (0-25 µM; 72 h) shows antiproliferative activity with IC50s of 0.04, 0.44, 0.27, 0.14, 0.75, 20.83 µM for MCF-7, PANC-1, HCT116, U-251, A549, NHDF (normal human fifibroblast) clls, respectively[1].
Anticancer agent 54 (1, 2.5, 5 µM; 24 h) induces cell cycle arrest at G0/G1 phases and apoptosis in a concentration-dependent manner[1].
Anticancer agent 54 (1 µM; 24 h) increases the reactive oxygen species (ROS) level[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 54 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 2.5, 5 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G0/G1 phases in a concentration-dependent manner.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 2.5, 5 µM
Incubation Time: 24 h
Result: The level of the apoptotic cells increased from 7.62% to 29.33% and the population of living cells decreased from 92.01% to 55.27% at 5 µM.
分子量

516.68

Formula

C33H36N6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 54 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 542933882-99-4Anticancer agent54Anticancer agent-54ApoptosisMCF-7 cellsapoptosisG0/G1ROSDNA intercalationanticancerantiproliferativeInhibitorinhibitorinhibit

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