2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 54

Anticancer agent 54 是一种有效的抗癌剂。Anticancer agent 54 显示出抗增殖活性。 Anticancer agent 54 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G0/G1 期。Anticancer agent 54 的抗癌活性取决于 DNA 嵌入和 ROS 生成。

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Anticancer agent 54 Chemical Structure

Anticancer agent 54 Chemical Structure

CAS No. : 2933882-99-4

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Anticancer agent 54 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.75 μM
Compound: Table 1, R1C1
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 31962262]
HCT-116 IC50
0.27 μM
Compound: Table 1, R1C1
Antiproliferative activity against human HCT 116 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against human HCT 116 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 31962262]
MCF7 IC50
0.039 μM
Compound: Table 1, R1C1
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CuSO4 by MTS assay
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CuSO4 by MTS assay
[PMID: 31962262]
MCF7 IC50
0.04 μM
Compound: Table 1, R1C1
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 31962262]
MCF7 IC50
1 μM
Compound: Table 1, R1C1
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeSO4 by MTS assay
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeSO4 by MTS assay
[PMID: 31962262]
MCF7 IC50
1 μM
Compound: Table 1, R1C1
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeCl3 by MTS assay
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of FeCl3 by MTS assay
[PMID: 31962262]
MCF7 IC50
1 μM
Compound: Table 1, R1C1
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CdSO4 by MTS assay
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of CdSO4 by MTS assay
[PMID: 31962262]
MCF7 IC50
1 μM
Compound: Table 1, R1C1
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of ZnCl2 by MTS assay
Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability measured after 72 hrs in presence of ZnCl2 by MTS assay
[PMID: 31962262]
NHDF IC50
20.83 μM
Compound: Table 1, R1C1
Cytotoxicity against human NHDF cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
Cytotoxicity against human NHDF cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 31962262]
PANC-1 IC50
0.44 μM
Compound: Table 1, R1C1
Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 31962262]
U-251 IC50
0.14 μM
Compound: Table 1, R1C1
Antiproliferative activity against human U251 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against human U251 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 31962262]
体外研究
(In Vitro)

Anticancer agent 54 (compound L) (0-25 µM; 72 h) shows antiproliferative activity with IC50s of 0.04, 0.44, 0.27, 0.14, 0.75, 20.83 µM for MCF-7, PANC-1, HCT116, U-251, A549, NHDF (normal human fifibroblast) clls, respectively[1].
Anticancer agent 54 (1, 2.5, 5 µM; 24 h) induces cell cycle arrest at G0/G1 phases and apoptosis in a concentration-dependent manner[1].
Anticancer agent 54 (1 µM; 24 h) increases the reactive oxygen species (ROS) level[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 54 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 2.5, 5 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G0/G1 phases in a concentration-dependent manner.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 2.5, 5 µM
Incubation Time: 24 h
Result: The level of the apoptotic cells increased from 7.62% to 29.33% and the population of living cells decreased from 92.01% to 55.27% at 5 µM.
分子量

516.68

Formula

C33H36N6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 54 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 542933882-99-4Anticancer agent54Anticancer agent-54ApoptosisMCF-7 cellsapoptosisG0/G1ROSDNA intercalationanticancerantiproliferativeInhibitorinhibitorinhibit

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