2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis PARP
  4. Anticancer agent 71

Anticancer agent 71 (Compound 4b) 是一种有效的抗癌剂，可诱导细胞凋亡。Anticancer agent 71 细胞周期停滞在 G2/M 期，并通过上调 Bax、Ikb-α 和切割 PARP 并下调 Bcl-2 表达水平诱导细胞凋亡。Anticancer agent 71 显示出抗增殖活性。

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Anticancer agent 71 Chemical Structure

Anticancer agent 71 Chemical Structure

CAS No. : 2453228-45-8

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Anticancer agent 71 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

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生物活性

Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity[1].

体外研究
(In Vitro)

Anticancer agent 71 (Compound 4b) (0.1-50 μM, 24 hours; SW480 and PC3 cells) increases the cytotoxicity and exerts potent antitumor activities against SW480 and PC3 cells[1].
Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours; SW480 cells) induces a significant G2/M phase arrest[1].
Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours) induces apoptosis in SW480 cells by upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 71 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: SW480 and PC3 cells
Concentration: 0.1, 1, 12.5, 25 and 50 μM
Incubation Time: 24 hours
Result: Inhibited with IC50 values of 11.08 and 17.39 μM for SW480 and PC3 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: SW480 cells
Concentration: 11.08 μM
Incubation Time: 24 hours
Result: The cell population percent at G2/M phase increased to 45.3%.

Apoptosis Analysis[1]

Cell Line: SW480 cells
Concentration: 11.08 μM
Incubation Time: 24 hours
Result: The percentage of cells in early and late apoptosis was recorded as 5.69% and 3.52%, respectively.

Western Blot Analysis[1]

Cell Line: SW480 cells
Concentration: 11.08 μM
Incubation Time: 24 hours
Result: The expression of antiapoptotic protein Bcl-2 decreased and the expression of Pro apoptotic Bax increased.
分子量

407.78

Formula

C18H13ClF3N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 71 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 712453228-45-8Anticancer agent71Anticancer agent-71ApoptosisPARPpoly ADP ribose polymeraseBaxIkb-αBcl-2anticancerInhibitorinhibitorinhibit

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