1. Apoptosis
  2. Apoptosis
  3. Anticancer agent 99

Anticancer agent 99 (compound 2p)对 HepG2 细胞有较好的抗癌活性,其 IC50 值为 35.9 μM。Anticancer agent 99 可以诱导细胞凋亡(apoptosis),具有抗增殖作用。

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Anticancer agent 99 Chemical Structure

Anticancer agent 99 Chemical Structure

CAS No. : 2914922-83-9

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC50 value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect[1].

体外研究
(In Vitro)

Anticancer agent 99 (0-50 μM, 24 h)可直接上调 Bax 表达并诱导 HepG2 细胞系中的 caspase-3 依赖性细胞凋亡,具有抗增殖作用[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: HepG2 cell
Concentration: 25, 50 μM
Incubation Time: 24 h
Result: Increased mRNA transcript levels of pro-apoptotic Bax and Caspase-3 genes.
Reduced Akt protein levels in HepG2 cells.
Increased FoXO1, TXNIP and p27 protein levels in HepG2 cells.
分子量

379.38

Formula

C19H20F3N3O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Anticancer agent 99 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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