1. Anti-infection
  2. Fungal
  3. Antifungal agent 96

Antifungal agent 96 (Compound WZ-2) 是一种抗真菌 (Fungal) 剂,具有良好的血脑屏障通透性和脑穿透能力。Antifungal agent 96 抑制 C. neoformans H99 和 C. albicans 0304103 的生长,MIC 值分别为 0.016 和 32 μg/mL。

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Antifungal agent 96 Chemical Structure

Antifungal agent 96 Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antifungal agent 96 (Compound WZ-2) is an antifungal agent with good blood-brain barrier permeability and brain penetration. Antifungal agent 96 inhibits the growth of C. neoformans H99 and C. albicans 0304103 with MIC values of 0.016 and 32 μg/mL, respectively[1].

体外研究
(In Vitro)

Antifungal agent 96 (0.063, 2μg/mL; 24 h) 显著抑制 C. neoformans H99 的荚膜生长[1]
Antifungal agent 96 (0.063μg/mL; 24h) 抑制了 C. neoformans H99 的生物膜形成,抑制率超过90%[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Antifungal agent 96 (5 mg/kg; i.v.; daily; 3 days) 对小鼠中的 C. neoformansC. albicans 显示出有效的抗真菌功效[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: cryptococcal meningitis (CM) mice[1]
Dosage: 5 mg/kg
Administration: IV; daily for 3 days
Result: Significantly reduced the kidney C. albicans 0304103 burden of mice and the brain C. neoformans H99 burden of CM mice.
分子量

248.26

Formula

C11H8N2O3S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Antifungal agent 96 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Antifungal agent 96
目录号:
HY-161380
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