2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Antiproliferative agent-10

Antiproliferative agent-10 (compound 8) 是一种抗肿瘤钌(II)-三吡唑基甲烷复合物，可通过抑制线粒体钙摄入抑制癌细胞的生长。

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Antiproliferative agent-10 Chemical Structure

Antiproliferative agent-10 Chemical Structure

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Antiproliferative agent-10 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiproliferative agent-10 (compound 8) is an anti-tumour ruthenium(II)-tris-pyrazolylmethane complex that inhibits the growth of cancer cells by inhibiting mitochondrial calcium uptake[1].

体外研究
(In Vitro)

Antiproliferative agent-10 (compound 8) (2-20 μM, 72 h) has some anti-cancer cell proliferative activity and effectively induces apoptosis in HCT116 cells[1].
Antiproliferative agent-10 (15 μM, 24 h) shows HCT116 cell survival rates of 93% to 97% and ruthenium content of cell was 59.4 ng/106 cells, so that it can accumulate efficiently in the cells and promote their biological activity[1].
Antiproliferative agent-10 (10-32 μM, 5 h) can cause mitochondrial depolarization in a concentration-dependent manner and inhibit mitochondrial calcium uptake[1].
Antiproliferative agent-10 can inhibit the formation and growth of spheroids of HCT116 cells with an IC50 value of 12.1 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antiproliferative agent-10 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7 (breast), HeLa (cervical), 518A2 (melanoma), HCT116 (colon), RD (rhabdomyosarcoma)
Concentration: 2-20 μM
Incubation Time: 72 hours
Result: Inhibited the proliferation of MCF-7, HeLa, 518A2, HCT116 and RD with the IC50 values of 10, 15, 10, 8 and 6.6 μM, respectively.
分子量

757.66

Formula

C35H36Cl2N7PRu
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiproliferative agent-10 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-10Antiproliferative agent10Antiproliferative agent 10Mitochondrial Metabolismmetal complexrutheniumanti-tumourmitochondrialcalcium uptakeHCT116Inhibitorinhibitorinhibit

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