2. Autophagy Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Autophagy Reactive Oxygen Species
  4. Antiproliferative agent-5

Antiproliferative agent-5 (compound 4o) 对胃癌细胞增殖有明显的不可逆抑制作用。Antiproliferative agent-5 可引起细胞在 G2/M 期阻滞，诱导 ROS 积累，激活细胞自噬 (autophagy)。Antiproliferative agent-5 可用于抗癌研究。

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Antiproliferative agent-5 Chemical Structure

Antiproliferative agent-5 Chemical Structure

CAS No. : 2459892-41-0

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Antiproliferative agent-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiproliferative agent-5 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative agent-5 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative agent-5 can be used for researching anticancer[1].

IC50 & Target

ROS, Autophagy[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
> 10 μM
Compound: 4o
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
BGC-823 GI50
0.64 μM
Compound: 4o
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
EJ GI50
> 10 μM
Compound: 4o
Antiproliferative activity against human EJ cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human EJ cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
HGC-27 GI50
0.64 μM
Compound: 4o
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
MGC-803 GI50
0.64 μM
Compound: 4o
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
MKN-45 GI50
0.64 μM
Compound: 4o
Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
SGC-7901 GI50
0.64 μM
Compound: 4o
Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
SW-620 IC50
0.058 μM
Compound: 24
Reversal of resistance to paclitaxel-induced cytotoxicity in human SW-620/AD300 cells assessed as reduction in paclitaxel IC50 at 1 uM preincubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 4.23 +/- 0.50 uM)
Reversal of resistance to paclitaxel-induced cytotoxicity in human SW-620/AD300 cells assessed as reduction in paclitaxel IC50 at 1 uM preincubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 4.23 +/- 0.50 uM)
[PMID: 34723530]
分子量

597.49

Formula

C28H21BrN8OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiproliferative agent-5 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-52459892-41-0Antiproliferative agent5Antiproliferative agent 5AutophagyReactive Oxygen SpeciesGastric cancerAnticancerG2/M phaseMGC-803SGC-7901Inhibitorinhibitorinhibit

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