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  4. Antiproliferative agent-61

Antiproliferative agent-61是一种合成的β-卡啉基查尔克酮，具有显著的抗增殖活性。Antiproliferative agent-61在一系列固体肿瘤细胞系中表现出明显的效应，在乳腺癌中效果最为突出。Antiproliferative agent-61在对人类乳腺癌MCF-7细胞系的测试中，显示出IC50值分别为2.25和3.29 μM。Antiproliferative agent-61显著诱导乳腺癌细胞的DNA片段化和凋亡。Antiproliferative agent-61抑制MDM2与p53的相互作用，并促进MDM2的降解。

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Antiproliferative agent-61 Chemical Structure

Antiproliferative agent-61 Chemical Structure

CAS No. : 1613078-24-2

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Antiproliferative agent-61 相关抗体

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生物活性

Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2[1].

分子量

358.39

Formula

C22H18N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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Antiproliferative agent-61 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antiproliferative agent-611613078-24-2Antiproliferative agent61Antiproliferative agent 61OthersInhibitorinhibitorinhibit

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